Document Detail

The efficacy of prophylactic erythromycin in preventing vertical transmission of Ureaplasma urealyticum.
MedLine Citation:
PMID:  9259934     Owner:  NLM     Status:  MEDLINE    
To determine if prophylactic erythromycin alters the vertical transmission rate of Ureaplasma urealyticum. Randomized prospective study of 51 singleton pregnancies between 22 and 35 weeks' gestation with preterm premature rupture of membranes or preterm labor. Patients received oral erythromycin for 7 days in addition to routine prophylactic intravenous ampicillin or ampicillin alone. Lower genital colonization with U. urealyticum was 33 of 51 (65%). Vertical transmission of U. urealyticum was 25% (3 of 12) in the erythromycin group and 4 of 17 (24%) for the controls. The average interval from randomization to delivery was 303.5 hr in the erythromycin group and 70.9 hr for controls (p = 0.04). Although not statistically significant, histologic chorioamnionitis in patients colonized with Ureaplasma was lower in the erythromycin group (3 of 12, 25%) compared to the controls (10 of 17, 59%). Prophylactic erythromycin does not decrease vertical transmission of Ureaplasma. It may decrease the incidence of histologic chorioamnionitis and increase the latency period.
K K Ogasawara; T M Goodwin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of perinatology     Volume:  14     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-09-08     Completed Date:  1997-09-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
University of Southern California School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, California, USA.
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MeSH Terms
Administration, Oral
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis*
Chorioamnionitis / epidemiology,  microbiology,  prevention & control
Erythromycin / therapeutic use*
Follow-Up Studies
Gestational Age
Infectious Disease Transmission, Vertical / prevention & control*
Pregnancy Complications, Infectious / microbiology,  prevention & control*
Pregnancy Outcome
Prospective Studies
Ureaplasma Infections / drug therapy*,  epidemiology,  transmission*
Ureaplasma urealyticum / drug effects*,  isolation & purification
Reg. No./Substance:
0/Anti-Bacterial Agents; 114-07-8/Erythromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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