Document Detail

The efficacy of progesterone in achieving successful pregnancy: I. Prophylactic use during luteal phase in anovulatory women.
MedLine Citation:
PMID:  2883139     Owner:  NLM     Status:  MEDLINE    
We have previously shown that prophylactic supplementation of progesterone beginning in the luteal phase of patients treated with human menopausal gonadotropins (hMG) could reduce the risk of spontaneous abortions. The present study was initiated with 100 patients to evaluate the efficacy of a new progesterone therapeutic regime in patients requiring either hMG or clomiphene citrate. A significantly decreased risk of spontaneous abortion (6% vs. 28%) was seen in 50 patients prophylactically treated with progesterone as compared with 50 control patients. The progesterone regimen was then tried on 566 consecutive patients who were treated and conceived with hMG or clomiphene citrate, and approximately the same risk (6.2% by 20 weeks) was found. This incidence of spontaneous abortion is even less than the accepted risk for the general population.
J H Check; J S Chase; C H Wu; H G Adelson; M Teichman; A Rankin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of fertility     Volume:  32     ISSN:  0020-725X     ISO Abbreviation:  Int. J. Fertil.     Publication Date:    1987 Mar-Apr
Date Detail:
Created Date:  1987-06-09     Completed Date:  1987-06-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374717     Medline TA:  Int J Fertil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous / prevention & control*
Anovulation / drug therapy*
Clomiphene / therapeutic use
Drug Evaluation
Luteal Phase / drug effects*
Menotropins / therapeutic use
Ovulation Induction
Progesterone / therapeutic use*
Reg. No./Substance:
57-83-0/Progesterone; 61489-71-2/Menotropins; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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