Document Detail

The efficacy of preemptive ketamine and ropivacaine in pediatric patients: a placebo controlled, double-blind.
MedLine Citation:
PMID:  19021008     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We have evaluated and compared the preemptive efficacy of intravenous ketamine with placebo and caudal ropivacaine in pediatric patients going under elective hernia repair. METHODS: 60 ASAI-II pediatric patients ages between 1-12. The patients were divided into 3 groups randomly. Group K patients had 0.5mg/kg ketamine by intravenous route before induction,Group R patients had 0.7 mg/kg 0.2% ropivacaine caudally and 2ml normal saline intravenously,Group RK patients had 0.7 mg/kg 0.2% ropivacaine caudally and 0.5mg/kg ketamine by intravenous routeAll patients had standard anesthesia technique. Heart rate (HR), pulse oximetry, and systolic and diastolic blood pressure (BP), and BIS (bispectral index) were obtained during anesthesia, In addition, end-tidal carbon dioxide concentration was monitored. The efficacy of postoperative analgesia was documented by objective pain scale (OPS). Analgesic requirements during and after the surgery documented RESULTS: While there was no significant differences in fentanyl consumption between the groups GR and GRK, fentanyl consumption was found to be significantly higher in group K during anesthesia.When compared with GR and GRK, GK had significantly higher OPS values. During postoperative period Group K patients demanded for additional analgesics in significantly shorter time than group R and Group K patients. GK patients had consumed significantly higher amounts of acetaminophen after surgery CONCLUSION: Caudal application of ropivacaine in appropriate doses provides satisfactory peroperative and postoperative analgesia with no side effects in pediatric patient group going under elective hernia repair where as ketamine with the applied doses has no preemptive effect.
Gül Köknel Talu; N Süleyman Ozyalçin; Rukiye Balsak; Meltem Karadeniz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Aǧrı : Ağrı (Algoloji) Derneği'nin Yayın organıdır = The journal of the Turkish Society of Algology     Volume:  20     ISSN:  1300-0012     ISO Abbreviation:  Agri     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2010-09-15     Revised Date:  2010-11-01    
Medline Journal Info:
Nlm Unique ID:  9426197     Medline TA:  Agri     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Department Of Algology, Medical Faculty Of Istanbul University, Capa 34390 Istanbul, Turkey.
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MeSH Terms
Amides / therapeutic use*
Analgesics, Opioid / therapeutic use
Blood Pressure / drug effects
Child, Preschool
Double-Blind Method
Heart Rate / drug effects
Hernia / surgery*
Ketamine / therapeutic use*
Morphine / therapeutic use
Pain Measurement
Pain, Postoperative / prevention & control
Reg. No./Substance:
0/Amides; 0/Analgesics, Opioid; 0/Placebos; 57-27-2/Morphine; 6740-88-1/Ketamine; 84057-95-4/ropivacaine

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