Document Detail

The efficacy of perioperative antibiotic therapy on recovery following tonsillectomy in adults: randomized double-blind placebo-controlled trial.
MedLine Citation:
PMID:  1738544     Owner:  NLM     Status:  MEDLINE    
One hundred and one adult patients undergoing tonsillectomy for chronic/recurrent tonsillitis completed a prospective, randomized, double-blind, placebo-controlled study in which ticarcillin disodium and clavulanate potassium (Timentin) or placebo was administered intravenously at the time of surgery and for 12 hours postoperatively. The patients than received oral amoxicillin and clavulanate potassium (Augmentin) therapy or placebo for an additional seven days. Each patient kept a daily log to assess the incidence and severity of postoperative symptoms. Tonsillar core tissue at the time of surgery, as well as tonsillar fossa cultures after 7 days of treatment, were obtained. Those patients who received antibiotics fared consistently better in the immediate postoperative period compared with the placebo group. Specifically, patients in the antibiotic group experienced significantly less mouth odor, were able to tolerate a regular diet sooner, and resumed their normal activities earlier than did patients who received placebo. Patients who received antibiotics experienced fewer days with mouth odor (p = 0.004). In addition, on postoperative days 3 to 5, the antibiotic group was eating a regular diet (p = 0.05) and had returned to their routine activities earlier (p = 0.045) when compared with the placebo group. Perioperative antibiotic therapy was well tolerated and was effective in minimizing symptoms after tonsillectomy.
J R Grandis; J T Johnson; R M Vickers; V L Yu; M M Wagener; R L Wagner; K A Kachman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  106     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-19     Completed Date:  1992-03-19     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Department of Otolaryngology, Eye and Ear Institute of Pittsburgh, PA 15213.
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MeSH Terms
Amoxicillin / therapeutic use*
Amoxicillin-Potassium Clavulanate Combination
Clavulanic Acids / therapeutic use*
Double-Blind Method
Drug Therapy, Combination / therapeutic use
Halitosis / prevention & control
Postoperative Complications / prevention & control
Postoperative Period
Prospective Studies
Ticarcillin / therapeutic use*
Reg. No./Substance:
0/Clavulanic Acids; 26787-78-0/Amoxicillin; 34787-01-4/Ticarcillin; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination; 86482-18-0/ticarcillin-clavulanic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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