Document Detail

The efficacy of oral terbutaline after intravenous tocolysis.
MedLine Citation:
PMID:  8238158     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to investigate in a prospective, randomized study the efficacy of oral terbutaline after successful intravenous tocolysis in reducing preterm birth. STUDY DESIGN: Patients between 28 and 35 weeks' gestation with uterine contractions and change in cervical examination were treated with intravenous magnesium sulfate for 12 to 24 hours. After successful tocolysis patients were approached for study participation and randomized to receive either oral terbutaline or no therapy. The dose of terbutaline was individualized to achieve a maternal pulse > 100 beats/min, and terbutaline was continued until 36 completed weeks of gestation. Recurrent preterm labor (contractions with change in cervical examination) for either group was treated with intravenous magnesium sulfate, and subsequent treatment was based on the previous randomization. RESULTS: Fifty-five patients were enrolled (28 terbutaline, 27 no oral tocolytic). No difference was found between groups with respect to time gained (4.0 +/- 2.7 vs 4.6 +/- 3.1 weeks, p = 0.412), gestational age at delivery (35.6 +/- 2.7 vs 36.1 +/- 2.4 weeks, p = 0.562), > or = 37 weeks at delivery (nine vs 13, p = 0.291), recurrent preterm labor (10 vs four, p = 0.104), recurrent uterine contractions alone (five vs eight, p = 0.527), birth weight (2616 +/- 633 gm vs 2645 +/- 599 gm, p = 0.785), special care nursery admissions (eight vs six, p = 0.759), or neonatal respiratory distress syndrome (three vs two, p = 0.965). CONCLUSION: The use of oral terbutaline after successful parenteral tocolysis failed to reduce the rate of preterm birth.
B V Parilla; S L Dooley; J P Minogue; M L Socol
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  169     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-26     Completed Date:  1993-11-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  965-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois.
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MeSH Terms
Administration, Oral
Birth Weight
Infusions, Intravenous
Life Tables
Magnesium Sulfate / administration & dosage,  therapeutic use
Obstetric Labor, Premature / prevention & control*
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Regression Analysis
Terbutaline / administration & dosage,  therapeutic use*
Tocolysis / methods*
Treatment Outcome
Reg. No./Substance:
23031-25-6/Terbutaline; 7487-88-9/Magnesium Sulfate

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