| The efficacy of a novel chitosan gel on hemostasis after endoscopic sinus surgery in a sheep model of chronic rhinosinusitis. | |
| | |
MedLine Citation:
|
PMID: 19379616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Postoperative bleeding remains a major problem after endoscopic sinus surgery (ESS). Patients who continue to bleed after ESS are at risk of airway compromise from inhalation of blood clots or from aspiration of blood-stained vomitus. The aim of this study was to determine the in vivo efficacy of a novel gel on hemostasis after ESS in a sheep model of chronic rhinosinusitis. METHODS: Twenty-one sheep infested with Oestrus ovus underwent ESS with standardized mucosal injuries created at the anterior ethmoid region using a microdebrider. Immediately after injury a baseline bleeding time was taken using the Boezaart Surgical Field Grading Scale. Computer randomization was performed to either receive chitosan/dextran (CD) gel or no treatment (control). Boezaart bleeding scores were calculated for each side every 2 minutes. Each postoperative day videoendoscopy was performed to document crusting/CD gel dissolution. RESULTS: The CD gel side was significantly more hemostatic at 2, 4, and 6 minutes after injury. Average time to hemostasis was significantly better for the intervention side versus control side, 4.09 (+/-1.61) versus 6.57 (+/-2.20), respectively (p = 0.049). Complete hemostasis occurred by 6 minutes for all CD gel sides; however, control side bleeding was noted on three sides at 8 minutes and on one side at 10 minutes. There was no significant difference in crusts scores at days 1, 3, 7, and 14. CONCLUSION: In the sheep model of ESS, CD gel significantly improved hemostasis compared with the control at 2, 4, and 6 minutes after mucosal injury. |
| | |
Authors:
|
Rowan Valentine; Theo Athanasiadis; Stephen Moratti; Simon Robinson; Peter-John Wormald |
Related Documents
:
|
19512936 - Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia. 16010606 - Endoscopic band ligation as salvage therapy in patients with bleeding peptic ulcers not... 4448416 - Coagulation factor concentrate in the treatment of the haemorrhagic diathesis of fulmin... 6146586 - Somatostatin in the treatment of severe gastrointestinal bleeding from peptic origin. a... 23581636 - Delayed intracranial hypertension after cranial vault remodeling for nonsyndromic singl... 6630776 - Value of early postoperative epicardial programmed ventricular stimulation studies afte... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: American journal of rhinology & allergy Volume: 23 ISSN: 1945-8924 ISO Abbreviation: Am J Rhinol Allergy Publication Date: 2009 Jan-Feb |
Date Detail:
|
Created Date: 2009-04-21 Completed Date: 2009-05-26 Revised Date: 2011-11-10 |
Medline Journal Info:
|
Nlm Unique ID: 101490775 Medline TA: Am J Rhinol Allergy Country: United States |
Other Details:
|
Languages: eng Pagination: 71-5 Citation Subset: IM |
Affiliation:
|
Department of Surgery-Otorhinolaryngology, Head and Neck Surgery University of Adelaide, Adelaide, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Intranasal Animals Chitosan / administration & dosage* Disease Models, Animal Endoscopy / methods* Ethmoid Sinusitis / surgery* Gels Hemostasis, Endoscopic / methods* Hemostatics / administration & dosage Otorhinolaryngologic Surgical Procedures / methods* Postoperative Hemorrhage / therapy* Rhinitis / surgery* Sheep Video Recording |
| Chemical | |
Reg. No./Substance:
|
0/Gels; 0/Hemostatics; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preoperative prognostic factors for olfactory change after functional endoscopic sinus surgery.
Next Document: Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent.