Document Detail

The efficacy of nicotinamide gel 4% as an adjuvant therapy in the treatment of cutaneous erosions of pemphigus vulgaris.
MedLine Citation:
PMID:  20597951     Owner:  NLM     Status:  MEDLINE    
The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on the pathophysiology of PV, nicotinamide can block the process of blister formation through its anti-inflammatory properties. This study was conducted to evaluate the clinical effectiveness of nicotinamide gel in the treatment of skin lesions of PV. In a double-blind, placebo-controlled study, eight PV patients with a total of 60 skin lesions were treated by either nicotinamide or placebo gel. After 30 days of treatment, epithelialization index of the two groups was compared. The mean of the epithelialization index in skin lesions that received nicotinamide was significantly higher than that of the placebo group (26 vs. -5.8, p < 0.001). Our results were suggestive that nicotinamide gel can effectively be used as an adjunctive treatment for PV lesions.
Fariba Iraji; Laleh Banan
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Dermatologic therapy     Volume:  23     ISSN:  1529-8019     ISO Abbreviation:  Dermatol Ther     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  308-11     Citation Subset:  IM    
Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
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MeSH Terms
Administration, Topical
Adrenal Cortex Hormones / therapeutic use
Anti-Inflammatory Agents / administration & dosage*
Azathioprine / therapeutic use
Drug Therapy, Combination
Immunosuppressive Agents / therapeutic use
Middle Aged
Niacinamide / administration & dosage*
Pemphigus / drug therapy*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents; 0/Gels; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 98-92-0/Niacinamide

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