Document Detail


The efficacy of the newer antiepileptic drugs in controlling seizures in pregnancy.
MedLine Citation:
PMID:  24995555     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To assess the effectiveness of the newer antiepileptic drugs (AEDs)-in particular lamotrigine, topiramate, and levetiracetam-in controlling epileptic seizures in pregnant women.
METHODS: Analysis of data in the Australian Register of Antiepileptic Drugs in Pregnancy concerning seizure control in 1,534 pregnancies in women with AED-treated epilepsies.
RESULTS: In AED monotherapy (1,111 pregnancies), use of levetiracetam in pregnancies in the Australian Register was associated with levels of seizure control similar to those that applied for the major older AEDs carbamazepine and valproate, but with levels of seizure control superior to those associated with use of lamotrigine and topiramate.
SIGNIFICANCE: Levetiracetam shows promise as a satisfactory drug for controlling seizures in pregnancy. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.
Authors:
Frank J E Vajda; Terrence O'Brien; Cecilie Lander; Janet Graham; Mervyn Eadie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-3
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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