Document Detail

The efficacy of isosorbide-5-mononitrate on effort-induced electrocardiographic ischemic changes in patients with angina pectoris.
MedLine Citation:
PMID:  3654028     Owner:  NLM     Status:  MEDLINE    
The efficacy of isosorbide-5-mononitrate 40 mg twice a day was tested in 10 patients suffering from effort-induced angina pectoris. Patients were studied with ergometer testing 6 hours after drug administration on the first treatment day, and again 8 and 12 hours after medication at 3 weeks and 6 months of therapy. At comparable and maximal workloads the patients expressed significantly less ST segment depression on treatment than prior to treatment. No tolerance was observed. Isosorbide-5-mononitrate treatment was demonstrated to have a beneficial effect on exercise tolerance in patients suffering from stable angina in effort.
D Brunner; N Meshulam; J Weisbort
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  16     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-11-19     Completed Date:  1987-11-19     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Institute of Physiological Hygiene, Faculty of Medicine, Tel Aviv University, Holon, Israel.
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MeSH Terms
Angina Pectoris / drug therapy*,  physiopathology
Drug Evaluation
Exercise Test
Isosorbide Dinitrate / analogs & derivatives*,  therapeutic use
Middle Aged
Time Factors
Reg. No./Substance:
16051-77-7/isosorbide-5-mononitrate; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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