| The efficacy of intramuscular 15 methyl prostaglandin E2 in second-trimester abortion. Coagulation and hormonal aspects. | |
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MedLine Citation:
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PMID: 1115161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Termination of pregnancy in the second trimester is sometimes associated with serious complications. This led to clinical investigation seeking methods superior to the traditional technique utilizing hypertonic saline. Intra-amniotic administration of naturally occurring prostaglandin F2-alpha has been developed and appears to be advantageous--especially in the area of coagulation stability. This study describes a technique for intramuscular administration of a prostaglandin analogue--15 methyl prostaglandin E2. This analogue is much more potent than the natural compound. Administration to 32 patients resulted in abortion in 28. The coagulation milieu remained completely intact and all other parameters were similar to previous published data for prostaglandin administration. There were no infections in this group of patients. |
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Authors:
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T F Dillon; L L Phillips; A Risk; T Horiguchi; H Mootabar |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 121 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1975 Mar |
Date Detail:
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Created Date: 1975-05-21 Completed Date: 1975-05-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 584-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents
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administration & dosage* Abortion, Induced / adverse effects, methods* Adult Amniotic Fluid Blood Coagulation / drug effects* Blood Coagulation Tests Blood Platelets / drug effects Chemical Phenomena Chemistry Drug Evaluation Factor V / analysis Factor X / analysis Female Fibrinogen / analysis Gestational Age Humans Hydrocortisone / blood* Hypertonic Solutions / administration & dosage Injections, Intramuscular Leukocytes / drug effects Neutrophils / drug effects Pregnancy Pregnancy Trimester, Second Progesterone / blood* Prostaglandins / administration & dosage*, adverse effects Prothrombin Time Sodium Chloride / administration & dosage Thromboplastin Time Factors Uterus / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents; 0/Hypertonic Solutions; 0/Prostaglandins; 50-23-7/Hydrocortisone; 57-83-0/Progesterone; 7647-14-5/Sodium Chloride; 9001-24-5/Factor V; 9001-29-0/Factor X; 9001-32-5/Fibrinogen; 9035-58-9/Thromboplastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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