Document Detail


The efficacy of intramuscular 15 methyl prostaglandin E2 in second-trimester abortion. Coagulation and hormonal aspects.
MedLine Citation:
PMID:  1115161     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Termination of pregnancy in the second trimester is sometimes associated with serious complications. This led to clinical investigation seeking methods superior to the traditional technique utilizing hypertonic saline. Intra-amniotic administration of naturally occurring prostaglandin F2-alpha has been developed and appears to be advantageous--especially in the area of coagulation stability. This study describes a technique for intramuscular administration of a prostaglandin analogue--15 methyl prostaglandin E2. This analogue is much more potent than the natural compound. Administration to 32 patients resulted in abortion in 28. The coagulation milieu remained completely intact and all other parameters were similar to previous published data for prostaglandin administration. There were no infections in this group of patients.
Authors:
T F Dillon; L L Phillips; A Risk; T Horiguchi; H Mootabar
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  121     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-05-21     Completed Date:  1975-05-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  584-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / administration & dosage*
Abortion, Induced / adverse effects,  methods*
Adult
Amniotic Fluid
Blood Coagulation / drug effects*
Blood Coagulation Tests
Blood Platelets / drug effects
Chemical Phenomena
Chemistry
Drug Evaluation
Factor V / analysis
Factor X / analysis
Female
Fibrinogen / analysis
Gestational Age
Humans
Hydrocortisone / blood*
Hypertonic Solutions / administration & dosage
Injections, Intramuscular
Leukocytes / drug effects
Neutrophils / drug effects
Pregnancy
Pregnancy Trimester, Second
Progesterone / blood*
Prostaglandins / administration & dosage*,  adverse effects
Prothrombin Time
Sodium Chloride / administration & dosage
Thromboplastin
Time Factors
Uterus / drug effects
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Hypertonic Solutions; 0/Prostaglandins; 50-23-7/Hydrocortisone; 57-83-0/Progesterone; 7647-14-5/Sodium Chloride; 9001-24-5/Factor V; 9001-29-0/Factor X; 9001-32-5/Fibrinogen; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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