Document Detail

The efficacy of immunotherapy in patients who underwent superovulation with intrauterine insemination.
MedLine Citation:
PMID:  8557129     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if the immunotherapy with corticosteroids would improve pregnancy rate in infertile patients with ovulatory factor and patients with unexplained infertility who undergo superovulation with IUI. DESIGN: Prospective, controlled study. SETTING: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan, Seoul, Korea. PATIENTS: Nine-one infertile patients with ovulatory factors and 78 patients with unexplained infertility who underwent superovulation with IUI. RESULTS: The prevalence of autoantibodies (antinuclear antibody, lupus anticoagulant, anticardiolipin antibody, antidouble-stranded DNA antibody) was elevated significantly in patients with unexplained infertility compared with patients with ovulatory infertility (20.5% versus 3.3%). Forty-five patients with ovulatory factor underwent 72 cycles of superovulation with IUI, receiving corticosteroids. Thirty-eight patients with unexplained infertility underwent 75 cycles of superovulation with IUI, receiving corticosteroids. Forty-six patients with ovulatory factor who underwent 66 cycles of superovulation with IUI and 40 patients with unexplained infertility who underwent 75 cycles of superovulation with IUI served as controls, not receiving corticosteroids. In patients with ovulatory factor, there were no significant differences between the corticosteroid treatment group and control group in clinical pregnancy rate (38.9% versus 33.3%) or in spontaneous abortion rate (14.3% versus 13.6%). In patients with unexplained infertility, there was a significantly higher clinical pregnancy rate per cycle in the corticosteroid treatment group, with 45.3% (34/75) compared with 29.3% (22/75) in the control group but no difference between the corticosteroid treatment and control groups in spontaneous abortion rate (17.6% versus 13.6%). There were no side effects due to the use of corticosteroids.
C H Kim; Y K Cho; J E Mok
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  65     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-27     Completed Date:  1996-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
Immunosuppressive Agents / therapeutic use*
Infertility / immunology
Insemination, Artificial*
Prospective Studies
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents

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