| The efficacy of gadobenate dimeglumine (Gd-BOPTA) at 3 Tesla in brain magnetic resonance imaging: comparison to 1.5 Tesla and a standard gadolinium chelate using a rat brain tumor model. | |
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MedLine Citation:
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PMID: 16481906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The objectives of this study were to analyze the differences in contrast enhancement using gadobenate dimeglumine (Gd-BOPTA or MultiHance) at 3 T versus 1.5 T and to compare Gd-BOPTA with a standard gadolinium chelate, gadopentetate dimeglumine (Gd-DTPA or Magnevist), at 3 T in a rat glioma model. MATERIALS AND METHODS: Twelve rats with surgically implanted gliomas were randomized to either comparing Gd-BOPTA at 1.5 T versus 3 T (n=7) or comparing Gd-BOPTA and Gd-DTPA at 3 T (n=5). Matched T1-weighted spin-echo techniques were used for both comparisons and the order of examinations was randomized. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and lesion enhancement (LE) were evaluated using a region-of-interest analysis. A veterinary histopathologist evaluated all brain specimens. RESULTS: In the evaluation of Gd-BOPTA at 3 T and 1.5 T, there were significant increases in SNR, LE, and CNR at 3 T. Average increases in brain and tumor SNR were 93% (P<0.0001) and 92% (P<0.0001), respectively. CNR increased by 121% (P<0.0001). Comparison of Gd-BOPTA and Gd-DTPA at 3 T demonstrated significantly higher CNR and LE with Gd-BOPTA. CNR increased by 35% (P=0.002). LE increased by 44% (P=0.03). CONCLUSIONS: Gd-BOPTA provides significantly higher CNR at 3 T compared with 1.5 T and also demonstrates significantly higher CNR when compared with a standard Gd-chelate at 3 T. As a result of transient protein binding, Gd-BOPTA may be superior to standard gadolinium chelates in neurologic imaging at 3 T. |
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Authors:
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Val M Runge; Jonmenjoy Biswas; Bernd J Wintersperger; Shannon S Baumann; Carney B Jackson; Christoph U Herborn; Tushar Patel |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 41 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-16 Completed Date: 2006-07-13 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 244-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, Scott & White Clinic and Hospital, Texas A&M University Health Science Center, Temple Texas 76508, USA. runge@att.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Neoplasms / pathology* Contrast Media / pharmacokinetics* Female Gadolinium DTPA / pharmacokinetics* Glioma / pathology* Magnetic Resonance Imaging / methods* Meglumine / analogs & derivatives*, pharmacokinetics Organometallic Compounds / pharmacokinetics* Random Allocation Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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