Document Detail

The efficacy of ferrous bisglycinate and electrolytic iron as fortificants in bread in iron-deficient school children.
MedLine Citation:
PMID:  16512940     Owner:  NLM     Status:  MEDLINE    
Food fortification is an important long-term strategy for addressing micronutrient deficiencies. Finding the ideal Fe fortification compound, however, remains a challenge. In the present study the effect of ferrous bisglycinate as fortificant in brown bread was compared with that of electrolytic Fe among Fe-deficient school children in a randomised controlled trial. Children (n 160), aged 6-11 years, with serum ferritin <20 microg/l, were randomly assigned to one of three treatment categories: (i) standard unfortified bread; (ii) bread with electrolytic Fe as fortificant; and (iii) bread with ferrous bisglycinate as fortificant. Each child received four slices of bread (120 g) on school days, which supplied an average of 3.66 mg elemental Fe per intervention day for 137 d (2.52 mg/d for 75 d and 5.04 mg/d for 62 d) over a period of 7.5 months. Hb, serum ferritin, serum Fe and transferrin saturation were measured at baseline and at the end of the intervention. Significant treatment effects were observed for Hb (P = 0.013), serum Fe (P = 0.041) and transferrin saturation (P = 0.042) in the ferrous bisglycinate group, but not in the electrolytic Fe group. There were no significant intervention effects for serum ferritin in either treatment group. Overall, ferrous bisglycinate as Fe fortificant in brown bread performed better than electrolytic Fe in a group of Fe-deficient school children over a period of 7.5 months.
Martha E van Stuijvenberg; Cornelius M Smuts; Petronella Wolmarans; Carl J Lombard; Muhammad A Dhansay
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  95     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-03     Completed Date:  2006-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  532-8     Citation Subset:  IM    
Nutritional Intervention Research Unit, Medical Research Council, Tygerberg, South Africa.
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MeSH Terms
Ferritins / blood
Ferrous Compounds / administration & dosage*,  metabolism
Food, Fortified*
Glycine / administration & dosage*,  metabolism
Hemoglobins / analysis
Iron / administration & dosage,  blood,  deficiency*
Patient Compliance
Transferrin / analysis
Treatment Outcome
Reg. No./Substance:
0/Ferrous Compounds; 0/Hemoglobins; 0/ferrous bisglycinate; 11096-37-0/Transferrin; 56-40-6/Glycine; 7439-89-6/Iron; 9007-73-2/Ferritins

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