Document Detail

The efficacy of early amniotomy in nulliparous labor induction: a randomized controlled trial.
MedLine Citation:
PMID:  22959833     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to assess whether early amniotomy reduces the duration of labor or increases the proportion of subjects who are delivered within 24 hours in nulliparous patients who undergo labor induction.
STUDY DESIGN: We performed a randomized controlled trial that compared early amniotomy to standard management in nulliparous labor inductions. Inclusion criteria were nulliparity, singleton, term gestation, and a need for labor induction. Subjects were assigned randomly to early amniotomy (artificial rupture of membranes, ≤4 cm) or to standard treatment. There were 2 primary outcomes: (1) time from induction initiation to delivery and (2) the proportion of women who delivered within 24 hours.
RESULTS: Early amniotomy shortens the time to delivery by >2 hours (19.0 vs 21.3 hours) and increases the proportion of induced nulliparous women who deliver within 24 hours (68% vs 56%). These improvements in labor outcomes did not come at the expense of increased complications.
CONCLUSION: Early amniotomy is a safe and efficacious adjunct in nulliparous labor inductions.
George A Macones; Alison Cahill; David M Stamilio; Anthony O Odibo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-08-24
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-01-22     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403.e1-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Amnion / drug effects,  surgery*
Delivery, Obstetric
Drug Therapy, Combination
Labor, Induced / methods*
Misoprostol / therapeutic use
Oxytocics / therapeutic use
Oxytocin / therapeutic use
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Oxytocics; 50-56-6/Oxytocin; 59122-46-2/Misoprostol
Comment In:
Am J Obstet Gynecol. 2013 May;208(5):418-9   [PMID:  23313719 ]
Am J Obstet Gynecol. 2013 May;208(5):419   [PMID:  23313718 ]

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