| The efficacy of different moisturizers on barrier recovery in hairless mice evaluated by non-invasive bioengineering methods. A model to select the potentially most effective product. | |
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MedLine Citation:
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PMID: 9237008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Moisturizers (emollients) are used frequently on normal and diseased skin. However, only few studies have examined their effects in dynamic situations and in more clinically relevant settings. We evaluated the effect of 4 commonly used products in a hairless mice model after acute skin barrier perturbation with acetone. The efficacy was evaluated by measurement of the transepidermal water loss (TEWL) and electrical conductance at various time intervals during barrier repair. The test products were compared with acetone-treated air-exposed controls allowed to recover otherwise normally and with a known irritant product, chlorhexidine cream 1%. Locobase was the most effective product in correcting barrier function and significantly improved barrier function during early stages of barrier recovery (< 6 h) without interfering with late stages of barrier recovery (> 6 h). The irritant control product, chlorhexidine cream 1%, delayed barrier recovery in the late stages. The model makes it possible to evaluate the combined effects of exogenous and endogenous components on barrier repair and to select the potentially most effective products before performing more cumbersome and time-consuming field studies. |
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Authors:
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C G Mortz; K E Andersen; L Halkier-Sørensen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Contact dermatitis Volume: 36 ISSN: 0105-1873 ISO Abbreviation: Contact Derm. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-09-22 Completed Date: 1997-09-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7604950 Medline TA: Contact Dermatitis Country: DENMARK |
Other Details:
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Languages: eng Pagination: 297-301 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Odense University Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
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adverse effects Animals Anti-Infective Agents, Local / therapeutic use Cell Membrane Permeability / drug effects, physiology Chlorhexidine / therapeutic use Dermatitis, Irritant / drug therapy*, etiology Dermatologic Agents / therapeutic use* Disease Models, Animal Emollients / therapeutic use* Female Galvanic Skin Response / drug effects Mice Mice, Hairless Skin / cytology Skin Temperature / physiology Time Factors Water Loss, Insensible / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Dermatologic Agents; 0/Emollients; 55-56-1/Chlorhexidine; 67-64-1/Acetone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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