Document Detail

The efficacy of different moisturizers on barrier recovery in hairless mice evaluated by non-invasive bioengineering methods. A model to select the potentially most effective product.
MedLine Citation:
PMID:  9237008     Owner:  NLM     Status:  MEDLINE    
Moisturizers (emollients) are used frequently on normal and diseased skin. However, only few studies have examined their effects in dynamic situations and in more clinically relevant settings. We evaluated the effect of 4 commonly used products in a hairless mice model after acute skin barrier perturbation with acetone. The efficacy was evaluated by measurement of the transepidermal water loss (TEWL) and electrical conductance at various time intervals during barrier repair. The test products were compared with acetone-treated air-exposed controls allowed to recover otherwise normally and with a known irritant product, chlorhexidine cream 1%. Locobase was the most effective product in correcting barrier function and significantly improved barrier function during early stages of barrier recovery (< 6 h) without interfering with late stages of barrier recovery (> 6 h). The irritant control product, chlorhexidine cream 1%, delayed barrier recovery in the late stages. The model makes it possible to evaluate the combined effects of exogenous and endogenous components on barrier repair and to select the potentially most effective products before performing more cumbersome and time-consuming field studies.
C G Mortz; K E Andersen; L Halkier-Sørensen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  36     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-09-22     Completed Date:  1997-09-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  IM    
Department of Dermatology, Odense University Hospital, Denmark.
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MeSH Terms
Acetone / adverse effects
Anti-Infective Agents, Local / therapeutic use
Cell Membrane Permeability / drug effects,  physiology
Chlorhexidine / therapeutic use
Dermatitis, Irritant / drug therapy*,  etiology
Dermatologic Agents / therapeutic use*
Disease Models, Animal
Emollients / therapeutic use*
Galvanic Skin Response / drug effects
Mice, Hairless
Skin / cytology
Skin Temperature / physiology
Time Factors
Water Loss, Insensible / drug effects
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Dermatologic Agents; 0/Emollients; 55-56-1/Chlorhexidine; 67-64-1/Acetone

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