Document Detail


The efficacy of different moisturizers on barrier recovery in hairless mice evaluated by non-invasive bioengineering methods. A model to select the potentially most effective product.
MedLine Citation:
PMID:  9237008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Moisturizers (emollients) are used frequently on normal and diseased skin. However, only few studies have examined their effects in dynamic situations and in more clinically relevant settings. We evaluated the effect of 4 commonly used products in a hairless mice model after acute skin barrier perturbation with acetone. The efficacy was evaluated by measurement of the transepidermal water loss (TEWL) and electrical conductance at various time intervals during barrier repair. The test products were compared with acetone-treated air-exposed controls allowed to recover otherwise normally and with a known irritant product, chlorhexidine cream 1%. Locobase was the most effective product in correcting barrier function and significantly improved barrier function during early stages of barrier recovery (< 6 h) without interfering with late stages of barrier recovery (> 6 h). The irritant control product, chlorhexidine cream 1%, delayed barrier recovery in the late stages. The model makes it possible to evaluate the combined effects of exogenous and endogenous components on barrier repair and to select the potentially most effective products before performing more cumbersome and time-consuming field studies.
Authors:
C G Mortz; K E Andersen; L Halkier-Sørensen
Related Documents :
3354518 - Effects of positional restraint on oxygen saturation and heart rate following exercise.
9638028 - Changes in plasma volume following intense intermittent exercise in neutral and hot env...
10656978 - Biexponential recovery model of lumbar viscoelastic laxity and reflexive muscular activ...
7912478 - Recovery of mivacurium and doxacurium versus vecuronium in the isolated forearm.
9114808 - Testing the alexithymia hypothesis: physiological and subjective responses during relax...
18274948 - The multi-stage fitness test as a predictor of endurance fitness in wheelchair athletes.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  36     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-09-22     Completed Date:  1997-09-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Odense University Hospital, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetone / adverse effects
Animals
Anti-Infective Agents, Local / therapeutic use
Cell Membrane Permeability / drug effects,  physiology
Chlorhexidine / therapeutic use
Dermatitis, Irritant / drug therapy*,  etiology
Dermatologic Agents / therapeutic use*
Disease Models, Animal
Emollients / therapeutic use*
Female
Galvanic Skin Response / drug effects
Mice
Mice, Hairless
Skin / cytology
Skin Temperature / physiology
Time Factors
Water Loss, Insensible / drug effects
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Dermatologic Agents; 0/Emollients; 55-56-1/Chlorhexidine; 67-64-1/Acetone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Content and reactivity to product perfumes in fragrance mix positive and negative eczema patients. A...
Next Document:  Prevalence of gold contact hypersensitivity in the west of Scotland.