| The efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria in Laos. | |
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MedLine Citation:
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PMID: 12396318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area. |
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Authors:
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J-P Guthmann; S Kasparian; R Phetsouvanh; N Nathan; M Garcia; S Phompida; A Brockman; M Gastellu; D Legros |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Annals of tropical medicine and parasitology Volume: 96 ISSN: 0003-4983 ISO Abbreviation: Ann Trop Med Parasitol Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-24 Completed Date: 2002-11-29 Revised Date: 2009-05-18 |
Medline Journal Info:
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Nlm Unique ID: 2985178R Medline TA: Ann Trop Med Parasitol Country: England |
Other Details:
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Languages: eng Pagination: 553-7 Citation Subset: IM |
Affiliation:
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Epicentre, 8 rue Saint Sabin, 75011 Paris, France. jguthmann@epicentre.msf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Animals Antimalarials / therapeutic use* Child Child, Preschool Chloroquine / therapeutic use* Female Genotype Humans Infant Laos Malaria, Falciparum / drug therapy* Male Middle Aged Plasmodium falciparum / genetics Quality Control Recurrence Treatment Failure Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 54-05-7/Chloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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