Document Detail

The efficacy of amlodipine in myocardial ischemia.
MedLine Citation:
PMID:  2573266     Owner:  NLM     Status:  MEDLINE    
Calcium antagonists are among the most potent and efficacious drugs used in the treatment of angina pectoris. Amlodipine, a new member of this family of dihydropyridines, has a unique pharmacokinetic profile with high bioavailability and an extended period of pharmacodynamic activity. In formal randomized, double-blind, placebo-controlled trials with exercise tests carried out 24 hours after administration, amlodipine was significantly more effective than the placebo and comparable in efficacy with the calcium antagonist diltiazem and the beta-blocking drug nadolol. In addition to extending exercise capacity in patients with angina pectoris, amlodipine significantly reduces ECG evidence of myocardial ischemia. Amlodipine has also been found to be effective in reducing the anginal attack rate in patients with vasospastic angina. From the evidence available, it is concluded that once-daily treatment with amlodipine in the dose range of 5 to 10 mg is effective in improving exercise capacity and reducing anginal attack rate in patients with chronic stable angina pectoris and also those with vasospastic angina.
S H Taylor
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  American heart journal     Volume:  118     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-06     Completed Date:  1989-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1123-6     Citation Subset:  AIM; IM    
Department of Medical Cardiology, General Infirmary at Leeds, England.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Angina Pectoris / drug therapy
Angina Pectoris, Variant / drug therapy
Calcium Channel Blockers
Coronary Disease / drug therapy*
Dose-Response Relationship, Drug
Nifedipine / administration & dosage,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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