| The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review. | |
| | |
MedLine Citation:
|
PMID: 17517094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this systematic review was to evaluate the efficacy of amino acid-based formulas (AAF) in patients with cow's milk allergy (CMA). Studies were identified using electronic databases and bibliography searches. Subjects eligible for inclusion were patients of any age with CMA or symptoms suggestive of it. Comparisons of interest were AAF vs. extensively hydrolysed formula (eHF), AAF vs. soy-based formula (SF) and AAF vs. cow's milk or cow's milk-based formula. Outcomes of interest were gastrointestinal (GI), dermatological, respiratory and behavioural symptoms as well as growth. A total of 20 studies [three head-to-head randomized controlled trials (RCTs), three cross-over challenge RCTs, seven clinical trials (CTs) and seven case reports (CRs)] were included in the review. In infants with confirmed or suspected CMA, the use of an AAF was shown to be safe and efficacious. Findings from RCT comparisons of AAF with eHF showed that both formulas are equally efficacious at relieving the symptoms of CMA in confirmed or suspected cases. However, infants in specific subgroups (e.g. non-IgE mediated food-induced gastro-enterocolitis-proctitis syndromes with failure to thrive, severe atopic eczema, or with symptoms during exclusive breastfeeding) were more likely overall to benefit from AAF, as intolerance to eHF may occur. In such cases, symptoms persisting despite eHF feeding usually remit on AAF, and catch-up growth may be seen. Meta-analysis of the findings was not possible due to lack of homogenous reporting of outcomes in the original trials. This systematic review shows clinical benefit from use of AAF in both symptoms and growth in infants and children with CMA who fail to tolerate eHF. Further studies are required to determine the relative medical or economic value of initial treatment with AAF in infants at high risk of eHF intolerance. |
| | |
Authors:
|
D J Hill; S H Murch; K Rafferty; P Wallis; C J Green |
Related Documents
:
|
2294624 - Genetic and environmental influences on cord blood serum ige and on atopic sensitisatio... 3505524 - Allergic predisposition among infants with bronchiolitis. 18295874 - Weekly bull exchange shortens postpartum anestrus in suckled beef cows. 19889194 - Changes in faecal microbiota of infants with cow's milk protein allergy--a spanish pros... 6310534 - An outbreak of herpes simplex virus type 1 in an intensive care nursery. 9350094 - Audit of the implementation of selective neonatal bcg immunisation in south east london. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 37 ISSN: 0954-7894 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-05-22 Completed Date: 2007-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
|
Languages: eng Pagination: 808-22 Citation Subset: IM |
Affiliation:
|
Department of Allergy, Royal Children's Hospital, Melbourne, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids*
/
adverse effects Animals Breast Feeding / adverse effects Cattle Cross-Over Studies Databases, Factual Dermatitis, Atopic / diet therapy, immunology, pathology Enteritis / diet therapy, immunology, pathology Failure to Thrive / diet therapy, immunology, pathology Humans Immunoglobulin E / immunology Infant Infant Food* / adverse effects Infant Formula* Infant, Newborn Meta-Analysis as Topic Milk* / adverse effects Milk Hypersensitivity* / diet therapy, immunology, pathology Milk, Human* Proctitis / diet therapy, immunology, pathology Randomized Controlled Trials as Topic Soy Milk* |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development, validation and application of a chemiluminescent immunoassay for the measurement of cir...
Next Document: Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irrit...