| The efficacy of Domperidone (R 33812) in the treatment of postoperative vomiting. A double-blind study with a placebo. | |
MedLine Citation:
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PMID: 7008643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred patients (14-82 years) were given either domperidone 10 mg I.V. or a placebo after they had vomited postoperatively. The patients were then observed for six hours. A supplementary injection of domperidone 10 mg I.V. from an open supply was given if required. In the placebo group 47.9% of patients needed another injection but only 25% of patients in the domperidone group (p less than 0.01). Vomiting occurred later after domperidone than after the placebo (p less than 0.01). At the end of six hours 74% of patients in the domperidone group had no recurrence of vomiting compared with 38% in the control group. In this study neither vomiting nor the efficacy of domperidone were found to be related to the type of surgery, the type of anaesthetic or the physical status (ASA I-III) of the patient (p greater than 0.05). |
Authors:
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L van Leeuwen; J H Helmers |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Der Anaesthesist Volume: 29 ISSN: 0003-2417 ISO Abbreviation: Anaesthesist Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-04-24 Completed Date: 1981-04-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370525 Medline TA: Anaesthesist Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 490-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antiemetics / adverse effects, therapeutic use* Benzimidazoles / adverse effects, therapeutic use* Clinical Trials as Topic Domperidone Double-Blind Method Female Humans Male Middle Aged Piperidines / adverse effects, therapeutic use* Postoperative Complications / drug therapy* Random Allocation Vomiting / drug therapy*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 0/Benzimidazoles; 0/Piperidines; 57808-66-9/Domperidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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