Document Detail

The efficacy of Domperidone (R 33812) in the treatment of postoperative vomiting. A double-blind study with a placebo.
MedLine Citation:
PMID:  7008643     Owner:  NLM     Status:  MEDLINE    
One hundred patients (14-82 years) were given either domperidone 10 mg I.V. or a placebo after they had vomited postoperatively. The patients were then observed for six hours. A supplementary injection of domperidone 10 mg I.V. from an open supply was given if required. In the placebo group 47.9% of patients needed another injection but only 25% of patients in the domperidone group (p less than 0.01). Vomiting occurred later after domperidone than after the placebo (p less than 0.01). At the end of six hours 74% of patients in the domperidone group had no recurrence of vomiting compared with 38% in the control group. In this study neither vomiting nor the efficacy of domperidone were found to be related to the type of surgery, the type of anaesthetic or the physical status (ASA I-III) of the patient (p greater than 0.05).
L van Leeuwen; J H Helmers
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Der Anaesthesist     Volume:  29     ISSN:  0003-2417     ISO Abbreviation:  Anaesthesist     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370525     Medline TA:  Anaesthesist     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  490-3     Citation Subset:  IM    
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MeSH Terms
Antiemetics / adverse effects,  therapeutic use*
Benzimidazoles / adverse effects,  therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Middle Aged
Piperidines / adverse effects,  therapeutic use*
Postoperative Complications / drug therapy*
Random Allocation
Vomiting / drug therapy*,  etiology
Reg. No./Substance:
0/Antiemetics; 0/Benzimidazoles; 0/Piperidines; 57808-66-9/Domperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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