Document Detail


The effectual level of ursodeoxycholic acid in therapy for non-advanced chronic cholestasis is fifty percent of total serum bile acids.
MedLine Citation:
PMID:  1577228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ursodeoxycholic acid therapy (600 mg/day) was evaluated in twelve patients with non-advanced chronic cholestasis. Within four months, ursodeoxycholic acid replaced more than 50% of total bile acids in 8 patients and the reduction of serum gamma-glutamyltranspeptidase, alkaline phosphatase and transaminases averaged 30% or more. The serum levels of chenodeoxycholic acid depend on those of ursodeoxycholic acid, but are not related to those of biochemical parameters. Drug therapy was continued in three poor responders for 2-3 four-month periods. In one case an increase of the serum proportion of ursodeoxycholic acid was associated with a reduction in biochemical parameters. The other two cases had high serum levels of chenodeoxycholic acid and/or cholic acid throughout the entire course of treatment. While the treatment of chronic cholestasis requires an effectual serum proportion of ursodeoxycholic acid, it is important to distinguish endogenous persistent hyper-bile-acidemia from ursodeoxycholic acid-related acidemia.
Authors:
T Higuchi; N Hishida; T Isomura; H Takeshima; H Hayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  27     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-05     Completed Date:  1992-06-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  222-9     Citation Subset:  IM    
Affiliation:
Third Department of Medicine, Nagoya University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bile Acids and Salts / blood*
Cholangitis, Sclerosing / complications,  drug therapy*
Cholestasis / drug therapy,  etiology
Female
Humans
Liver Cirrhosis, Biliary / complications,  drug therapy*
Liver Function Tests
Male
Middle Aged
Ursodeoxycholic Acid / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid

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