| The effectual level of ursodeoxycholic acid in therapy for non-advanced chronic cholestasis is fifty percent of total serum bile acids. | |
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MedLine Citation:
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PMID: 1577228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ursodeoxycholic acid therapy (600 mg/day) was evaluated in twelve patients with non-advanced chronic cholestasis. Within four months, ursodeoxycholic acid replaced more than 50% of total bile acids in 8 patients and the reduction of serum gamma-glutamyltranspeptidase, alkaline phosphatase and transaminases averaged 30% or more. The serum levels of chenodeoxycholic acid depend on those of ursodeoxycholic acid, but are not related to those of biochemical parameters. Drug therapy was continued in three poor responders for 2-3 four-month periods. In one case an increase of the serum proportion of ursodeoxycholic acid was associated with a reduction in biochemical parameters. The other two cases had high serum levels of chenodeoxycholic acid and/or cholic acid throughout the entire course of treatment. While the treatment of chronic cholestasis requires an effectual serum proportion of ursodeoxycholic acid, it is important to distinguish endogenous persistent hyper-bile-acidemia from ursodeoxycholic acid-related acidemia. |
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Authors:
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T Higuchi; N Hishida; T Isomura; H Takeshima; H Hayashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterologia Japonica Volume: 27 ISSN: 0435-1339 ISO Abbreviation: Gastroenterol. Jpn. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-06-05 Completed Date: 1992-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0152744 Medline TA: Gastroenterol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 222-9 Citation Subset: IM |
Affiliation:
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Third Department of Medicine, Nagoya University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile Acids and Salts / blood* Cholangitis, Sclerosing / complications, drug therapy* Cholestasis / drug therapy, etiology Female Humans Liver Cirrhosis, Biliary / complications, drug therapy* Liver Function Tests Male Middle Aged Ursodeoxycholic Acid / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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