Document Detail

The effects of zinc sulphate on hypercholesterolaemia induced by cholesterol-choleate in rats.
MedLine Citation:
PMID:  4034627     Owner:  NLM     Status:  MEDLINE    
The effects of zinc sulphate on cholesterol-choleate-induced hypercholesterolaemia were studied in rats. Zinc sulphate (20 or 40 mg/kg, p.o. once daily for 5 days) administration, which raised serum zinc levels, significantly increased bile acid secretion and lowered high-density lipoprotein-cholesterol (HDL-C) levels in the serum. Cholesterol-choleate, given by the same route and schedule, markedly elevated serum total cholesterol level, but decreased serum HDL-C concentration. Bile acid in serum and in bile was also increased, but these changes were inhibited by zinc sulphate pretreatment. Zinc sulphate also worsened the decrease in HDL-C and slightly prolonged the elevation in total cholesterol produced by cholesterol-choleate administration. It is concluded that the moderate increase in serum total cholesterol level by zinc sulphate could be due to inhibition of hepatic metabolism of cholesterol to bile acid. The specific action of zinc ions on HDL-C metabolism is discussed.
C H Cho; S M Chen; C W Ogle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological research communications     Volume:  17     ISSN:  0031-6989     ISO Abbreviation:  Pharmacol Res Commun     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-10-03     Completed Date:  1985-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0236354     Medline TA:  Pharmacol Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-45     Citation Subset:  IM    
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MeSH Terms
Bile / metabolism
Bile Acids and Salts / blood,  metabolism
Cholesterol / metabolism
Cholesterol, HDL / blood
Deoxycholic Acid / metabolism
Hypercholesterolemia / chemically induced,  drug therapy*
Rats, Inbred Strains
Sulfates / therapeutic use*
Zinc / blood,  metabolism,  therapeutic use*
Zinc Sulfate
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholesterol, HDL; 0/Sulfates; 57-88-5/Cholesterol; 7440-66-6/Zinc; 7733-02-0/Zinc Sulfate; 83-44-3/Deoxycholic Acid

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