Document Detail

The effects of xylazine on intrauterine pressure, uterine blood flow, maternal and fetal cardiovascular and pulmonary function in pregnant goats.
MedLine Citation:
PMID:  8777227     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of xylazine on pregnant goats, xylazine induced changes in heart rate (HR), arterial blood pressure (ABP) and arterial blood pH and gases in the mother and fetus, as well as changes in intrauterine pressure (IUP) and uterine blood flow (UBF), were studied using a chronic preparation model of pregnant goats. Intramuscular administration of xylazine (0.2 mg/kg b.w.) caused a marked decrease in HR and ABP of the mother, which remained significantly reduced up to 120 min. In the fetus, a significant decrease in HR and a significant increase in ABP were recorded after only 5 min. Significant decreases of maternal arterial blood pH and oxygen partial pressure (Po2) were observed up to 120 and 30 min after the injection, respectively. Fetal arterial blood pH and Po2 also decreased, but these changes were milder and less persistent than those of the mother. Within 2 to 5 min after the administration of xylazine, IUP began to increase and remained high for about 15 min. Thereafter, there was a frequent periodic increase in IUP. After 5 min, UBF decreased significantly and remained low up to 120 min. A fall in UBF was associated with a rise in IUP. These findings suggested that administration of xylazine to pregnant goats results in a decrease in UBF arising from the induction of uterine contractions, a decrease in circulating blood volume, hypoxemia and acidosis in the mother.
H Sakamoto; K Misumi; M Nakama; Y Aoki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  58     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-16     Completed Date:  1996-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  211-7     Citation Subset:  IM    
Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan.
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MeSH Terms
Blood Pressure / drug effects
Carbon Dioxide / blood
Heart / drug effects,  embryology,  physiology*
Heart Rate / drug effects
Heart Rate, Fetal / drug effects,  physiology
Hydrogen-Ion Concentration
Lung / drug effects,  embryology,  physiology*
Oxygen / blood
Partial Pressure
Pregnancy, Animal / physiology*
Regional Blood Flow / drug effects
Time Factors
Uterus / blood supply,  drug effects,  physiology*
Xylazine / pharmacology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7361-61-7/Xylazine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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