Document Detail

The effects of vitamin E deficiency on rat skin.
MedLine Citation:
PMID:  2757955     Owner:  NLM     Status:  MEDLINE    
The effect of vitamin E deficiency on the levels of lipid peroxide and solubility of collagen was investigated in Wistar rats that were fed a vitamin E deficient diet for 3 and 6 months. The lipid peroxide content in the skin and subcutaneous tissue was markedly increased as compared with that of control rats on a normal diet. The lipid peroxide content in the tissues of rats deficient in vitamin E for 3 months, was greater than that found in those on the diet for 6 months. The effect of UV irradiation on the lipid peroxide content in the skin of control rats was not significant, but there was a marked difference in lipid peroxide content in those animals on a deficient diet. The amount of insoluble collagen in the skin of rats on a vitamin E deficient diet for 6 months was increased and by more than in those animals on the diet for 3 months. The amount of soluble collagen in the rats deficient in vitamin E for 6 months was markedly reduced when compared with those on the diet for 3 months. These results suggest that vitamin E deficiency promotes the peroxidation of lipids and accelerates the cross-linking of collagen in the skin.
A Igarashi; M Uzuka; K Nakajima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  121     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-19     Completed Date:  1989-09-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Shiseido Laboratories, Yokohama, Japan.
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MeSH Terms
Collagen / metabolism
Lipid Peroxides / metabolism
Rats, Inbred Strains
Skin / metabolism*
Vitamin E Deficiency / metabolism*
Reg. No./Substance:
0/Lipid Peroxides; 9007-34-5/Collagen

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