Document Detail

The effects of verapamil and propranolol on exercise tolerance in hypertensive patients.
MedLine Citation:
PMID:  3552358     Owner:  NLM     Status:  MEDLINE    
In a single-blind, placebo-controlled crossover study the effects of verapamil (450 +/- 30 mg/day) and propranolol (160 +/- 20 mg/day) on endurance time during submaximal exercise were compared in eight patients with essential hypertension. The drugs were given in randomized order. Each active drug period was preceded by a placebo phase. Endurance tests were performed during both placebo periods and treatment with verapamil and propranolol by bicycle ergometry. Both drugs were equally effective in decreasing resting blood pressure. Verapamil and propranolol reduced exercise heart rate, the effect of propranolol being more pronounced. With placebo, endurance time during exercise was 57 +/- 11 minutes; with propranolol it was 32 +/- 7 minutes (P less than 0.05). Verapamil had no influence on endurance time. The study demonstrates that in contrast to propranolol, verapamil has no influence on exercise tolerance during submaximal work in patients with hypertension.
J Mooy; M van Baak; R Böhm; R Does; H Petri; J van Kemenade; K H Rahn
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  41     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-22     Completed Date:  1987-06-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  490-5     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Hypertension / drug therapy*,  physiopathology
Middle Aged
Physical Endurance / drug effects*
Propranolol / therapeutic use*
Random Allocation
Verapamil / therapeutic use*
Reg. No./Substance:
52-53-9/Verapamil; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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