| The effects of vasopressor and vasodilator on hemodynamic energy in terms of surplus hemodynamic energy. | |
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MedLine Citation:
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PMID: 18812748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study, we reported that inotropic agents affect the hemodynamic energy, which can be measured using the energy equivalent pressure (EEP) and surplus hemodynamic energy (SHE). However, there has been no study about the effect of vasopressors and vasodilators on EEP and SHE. Thus, we investigated the change in the hemodynamic energy induced by phenylephrine, nitroprusside, norepinephrine, and milrinone in terms of the EEP and SHE. Phenylephrine (1, 3 microg/kg/min), nitroprusside (0.5, 1 microg/kg/min), norepinephrine (0.1, 0.25 microg/kg/min), and milrinone (bolus 50 microg/kg, followed by 0.5, 0.7 microg/kg/min) were infused into 13 anesthetized dogs. The hemodynamic parameters, mean arterial pressure (MAP), and flow were recorded in the descending thoracic aorta, and EEP and SHE were calculated. MAP, EEP, and SHE increased significantly with phenylephrine administration. However, the flow in the descending aorta decreased significantly (p < 0.05). Norepinephrine also significantly increased MAP, EEP, and SHE (p < 0.05 in all cases). The MAP, EEP, and SHE significantly decreased after nitroprusside infusion (p < 0.05), whereas milrinone did not have an effect on MAP, EEP, or SHE. In conclusion, vasopressors were found to increase EEP and SHE, while a vasodilator decreased EEP and SHE. |
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Authors:
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Choon Hak Lim; Sung Yang; Ho Sung Son; Jung Joo Lee; Jun Rho Yoon; Sung Ho Lee; Hye Won Lee; Kyung Sun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 54 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2008 Sep-Oct |
Date Detail:
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Created Date: 2008-09-24 Completed Date: 2008-11-13 Revised Date: 2009-03-19 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 534-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Pain Medicine, Korea University, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / drug effects Blood Flow Velocity / drug effects* Blood Pressure / drug effects* Dogs Dose-Response Relationship, Drug Hemodynamics / drug effects* Milrinone / pharmacology Nitroprusside / pharmacology Norepinephrine / pharmacology Phenylephrine / pharmacology Vasoconstrictor Agents / pharmacology* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine; 78415-72-2/Milrinone |
| Comments/Corrections | |
Erratum In:
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ASAIO J. 2009 Jan-Feb;55(1):125 Note: Yang, Sung [added] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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