Document Detail


The effects of vasoactivity and hypoxic pulmonary hypertension on extralobar pulmonary artery biomechanics.
MedLine Citation:
PMID:  20416876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Loss of large artery compliance is an emerging novel predictor of cardiovascular mortality. Hypoxia-induced pulmonary hypertension (HPH) has been shown to decrease extralobar pulmonary artery (PA) compliance in the absence of smooth muscle cell (SMC) tone and to increase SMC tone in peripheral PAs. We sought to determine the impact of HPH on extralobar PA tone and the impact of SMC activation on extralobar PA biomechanics. To do so, C57BL6 mice were exposed to 0 (CTL) or 10 days (HPH) of hypoxia and isolated vessel tests were performed on extralobar PAs using either a physiological saline solution (PSS), a vasoconstrictor (U46619), two vasodilators (SNP and Y27632) or calcium free medium (relaxant solution; VBRS). The vasodilators and relaxant solution had no effect on extralobar artery diameter suggesting that basal SMC tone is essentially zero in CTL conditions and does not increase with HPH. HPH caused narrowing, decreased circumferential stretch (lambda; p<0.0001), decreased local area compliance (C(A); p<0.0005) and increased incremental elastic modulus (E(inc); p<0.05) in the normal tone state (with PSS). In both CTL and HPH conditions, SMC activation decreased E(inc) (p<0.0005) but also increased wall thickness (p<0.05) such that changes in C(A) with SMC constriction were minimal; only in HPH PAs was a significant decrease with SMC constriction observed (p<0.05). Our results demonstrate that 10 days of hypoxia does not increase extralobar PA SMC tone and that HPH-induced decreases in compliance are caused by narrowing, wall thickening and increases in modulus, not persistent vasoconstriction.
Authors:
Diana M Tabima; Naomi C Chesler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-04-22
Journal Detail:
Title:  Journal of biomechanics     Volume:  43     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-29     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1864-9     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
Amides / pharmacology
Animals
Biomechanical Phenomena
Cell Hypoxia
Hypertension, Pulmonary / metabolism*
Male
Mice
Muscle, Smooth, Vascular / drug effects,  physiology*
Pulmonary Artery / drug effects,  physiology*
Pyridines / pharmacology
Vasoconstriction / physiology
Vasoconstrictor Agents / pharmacology
Vasodilation / physiology
Grant Support
ID/Acronym/Agency:
1UL1RR025011/RR/NCRR NIH HHS; R01 HL086939/HL/NHLBI NIH HHS; R01 HL086939-03/HL/NHLBI NIH HHS; R01HL086939/HL/NHLBI NIH HHS; UL1 RR025011/RR/NCRR NIH HHS; UL1 RR025011-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Amides; 0/Pyridines; 0/Vasoconstrictor Agents; 138381-45-0/Y 27632; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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