Document Detail


The effects of two forms of physical activity on eyeblink classical conditioning.
MedLine Citation:
PMID:  21238502     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Voluntary exercise, in the form of free access to a running wheel in the home cage, has been shown to improve several forms of learning and memory. Acrobatic training, in the form of learning to traverse an elevated obstacle course, has been shown to induce markers of neural plasticity in the cerebellar cortex in rodents. In three experiments, we examined the effects of these two forms of physical activity on delay eyeblink conditioning in rats. In Experiment 1, exercising rats were given 17 days of free access to a running wheel in their home cage prior to 10 days of delay eyeblink conditioning. Rats that exercised conditioned significantly better and showed a larger reflexive eyeblink unconditioned response to the periocular stimulation unconditioned stimulus than rats that did not exercise. In Experiment 2, exercising rats were given 17 days of free access to a running wheel in their home cage prior to 10 days of explicitly unpaired stimulus presentations. Rats that exercised responded the same to tone, light, and periocular stimulation as rats that did not exercise. In Experiment 3, acrobatic training rats were given 15 days of daily training on an elevated obstacle course prior to 10 days of eyeblink conditioning. Activity control rats underwent 15 days of yoked daily running in an open field. Rats that underwent acrobatic training did not differ in eyeblink conditioning from activity control rats. The ability to measure the learned response precisely, and the well-mapped neural circuitry of eyeblink conditioning offer some advantages for the study of exercise effects on learning and memory.
Authors:
John T Green; Amy C Chess; Montana Burns; Kira M Schachinger; Alexandra Thanellou
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-14
Journal Detail:
Title:  Behavioural brain research     Volume:  219     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-13     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  165-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Amygdala / physiology
Animals
Cerebellum / physiology
Conditioning, Eyelid / physiology*
Data Interpretation, Statistical
Male
Physical Conditioning, Animal / physiology*
Rats
Rats, Wistar
Running / psychology
Grant Support
ID/Acronym/Agency:
R01 MH082893/MH/NIMH NIH HHS; R01 MH082893/MH/NIMH NIH HHS; R01 MH082893-01A1/MH/NIMH NIH HHS
Comments/Corrections

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