| The effects of tritium on embryo development: the embryotoxic effects of [3H]tryptophan. | |
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MedLine Citation:
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PMID: 2569016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of tritiated amino acids on the development of the early mouse embryo in vitro are described. [3H]tryptophan was extremely toxic, compared with [3H]glutamic acid, and inhibited growth of the two-cell embryo to the blastocyst stage. The LD50 values for the two amino acids were, respectively, 1 and 296 kBq/ml of medium. The two-cell embryo was more sensitive to the irradiation from incorporated [3H]tryptophan is selectively incorporated into two chromosomal proteins in the two-cell embryo, and that those proteins were stage-specific markers of development. |
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Authors:
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H M Killen; J Carroll |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: International journal of radiation biology Volume: 56 ISSN: 0955-3002 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-05 Completed Date: 1989-09-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 139-49 Citation Subset: IM; S |
Affiliation:
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Department of Biochemistry, Trinity College, Dublin, Republic of Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Blastocyst / radiation effects* Cell Compartmentation Chromosomes / metabolism Cleavage Stage, Ovum / radiation effects* Embryo Implantation Female Glutamates / metabolism Glutamic Acid Leucine / metabolism Mice / embryology* Molecular Weight Nuclear Proteins / biosynthesis Protein Biosynthesis RNA, Messenger / metabolism Tritium / toxicity* Tryptophan / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Nuclear Proteins; 0/RNA, Messenger; 10028-17-8/Tritium; 56-86-0/Glutamic Acid; 61-90-5/Leucine; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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