Document Detail


The effects of transport perturbations on the homeostasis of erythrocytes.
MedLine Citation:
PMID:  10645537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The control of erythrocyte volume, pH, membrane potential and ion content results from the interaction of many passive and active transport systems, cytoplasmic buffers, and from the charge and osmotic properties of haemoglobin and other impermeant solutes. The complexity of the system is such that the understanding of cell responses to experimental, physiological and pathophysiological challenges is beyond intuitive grasp. Mathematical models of erythrocyte and reticulocyte homeostasis have delivered a wealth of novel and unexpected predictions that have been confirmed experimentally. Those concerning effects of Ca(2)+ and K+ permeabilization on cell volume, pH and osmolality have helped solve long-standing issues on the pathophysiology of sickle-cell dehydration and will be briefly reviewed here. To study the effects of parasite growth and of new permeation pathways (NPP) on host cell homeostasis, we have developed a model of a Plasmodium falciparum- infected erythrocyte. Modelling NPP to fit reported changes in both Na+/K+ fluxes and gradients predicted large variations in host cell haemoglobin concentration, [Hb]. However, preliminary estimates seem to indicate that host cell [Hb] is conserved throughout the parasite's asexual cycle, suggesting that the properties of the NPP vary in subtle, stage-dependent ways.
Authors:
V L Lew; A R Hockaday
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Novartis Foundation symposium     Volume:  226     ISSN:  1528-2511     ISO Abbreviation:  Novartis Found. Symp.     Publication Date:  1999  
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9807767     Medline TA:  Novartis Found Symp     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  37-50; discussion 50-4     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport, Active
Calcium / metabolism
Cell Membrane Permeability
Erythrocytes / metabolism,  parasitology*
Homeostasis*
Humans
Membrane Potentials
Models, Biological
Plasmodium*
Potassium / metabolism
Chemical
Reg. No./Substance:
7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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