| The effects of topical corticosteroids and a coal tar preparation on dithranol-induced irritation in patients with psoriasis. | |
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MedLine Citation:
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PMID: 12566824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dithranol has been a mainstay in the treatment of psoriasis for more than 80 years. Although a safe approach, the irritation of the clinically uninvolved perilesional skin remains a major limitation of this treatment. Corticosteroids and coal tar solution have an anti-inflammatory potential. The aim of the present study was to investigate the clinical and cell-biological effects of two topical corticosteroids and a coal tar preparation on dithranol-irritated skin. During 4 consecutive days, 2% dithranol cream was applied to six uninvolved skin sites (3 cm in diameter) on the lower back of 9 patients with psoriasis. Dithranol was left on the skin for 1 h, subsequently removed with water and soap and the skin was dried with a towel. Subsequently, SITE 1 was treated with 0.05% clobetasol-17-propionate ointment (CP), SITE 2 with unguentum cetomacrogolis (vehicle 1), SITE 3 with 0.005% fluticasonpropionate ointment (FP), SITE 4 with 10% coal tar solution in lanettewax cream (CTS), SITE 5 was left untreated (control) and SITE 6 was treated with lanettewax cream (vehicle 2). Erythema, oedema and vesicle formation was scored every day. On day 5, punch biopsies were taken from the six sites. The expression of epidermal proliferation, differentiation and inflammation markers and the clinical irritation scores indicate that the application of a high potency corticosteroid (CP) is the best approach to minimise dithranol irritation, whereas CTS had virtually no effect on dithranol irritation during this 4-day experimental model. |
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Authors:
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O Q J Swinkels; M Kucharekova; M Prins; M J P Gerritsen; P G M van der Valk; P C M van de Kerkhof |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Skin pharmacology and applied skin physiology Volume: 16 ISSN: 1422-2868 ISO Abbreviation: Skin Pharmacol. Appl. Skin Physiol. Publication Date: 2003 Jan-Feb |
Date Detail:
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Created Date: 2003-02-04 Completed Date: 2003-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9807277 Medline TA: Skin Pharmacol Appl Skin Physiol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 12-7 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Department of Dermatology University Medical Centre Nijmegen, Nijmegen, The Netherlands. O.Swinkels@derma.azn.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Aged, 80 and over Androstadienes / administration & dosage, therapeutic use Anthralin / administration & dosage, adverse effects*, therapeutic use Anti-Inflammatory Agents / administration & dosage, adverse effects*, therapeutic use* Cell Division / drug effects Clobetasol / administration & dosage, analogs & derivatives*, therapeutic use Coal Tar / administration & dosage, therapeutic use* Erythema / chemically induced, drug therapy* Female Glucocorticoids Humans Macrophages / drug effects Male Middle Aged Monocytes / drug effects Psoriasis / drug therapy* Skin / drug effects, pathology T-Lymphocytes / drug effects Vehicles |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 0/Anti-Inflammatory Agents; 0/Glucocorticoids; 0/Vehicles; 25122-41-2/Clobetasol; 480-22-8/Anthralin; 8007-45-2/Coal Tar; 90566-53-3/fluticasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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