Document Detail


The effects of thiotepa, mitomycin C, BCG and interferon instillation on urothelium.
MedLine Citation:
PMID:  8738618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of Thiotepa, Mitomycin C, BCG and Interferon on urothelium were researched in rabbits. Early changes of a contracted bladder such as fibroblastic atypia and sub-epithelial plaque were seen in all groups in different rates. This rate in the Thiotepa and BCG groups was 100% and in the Mitomycin C and Interferon groups 60%. There was no urothelial dysplasia in the BCG and Interferon groups, whereas in the Thiotepa group 100% and in the Mitomycin C group 40% were seen. In conclusion, urothelial dysplasia or fibroblastic atypia in random biopsies were criteria to prevent further complications in intravesical therapies.
Authors:
O Polat; C Gündoğdu; A Demirel; Y Bayraktar; O Gül; M Ozbilge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International urology and nephrology     Volume:  28     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  1996  
Date Detail:
Created Date:  1996-10-16     Completed Date:  1996-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
Affiliation:
Department of Urology, Atatürk University School of Medicine, Research Hospital, Erzurum, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravesical
Animals
Antineoplastic Agents / pharmacology*
BCG Vaccine / pharmacology*
Epithelium / drug effects,  pathology
Interferons / pharmacology*
Mitomycin / pharmacology*
Rabbits
Thiotepa / pharmacology*
Urinary Bladder / drug effects*,  pathology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/BCG Vaccine; 50-07-7/Mitomycin; 52-24-4/Thiotepa; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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