Document Detail

The effects of theophylline on the physical performance and work capacity of well-trained athletes.
MedLine Citation:
PMID:  2913139     Owner:  NLM     Status:  MEDLINE    
Theophylline, a pharmacologic agent presently permitted during international sporting competition, has come under scrutiny because of the suggestion that it may be ergogenic. This study examined the effects of serum theophylline levels of 10 to 20 mg/L and the administration of a placebo on selected measures of physical performance and work capacity to determine any ergogenic outcomes. Seven male and three female elite athletes from a variety of team sports and aged 18 to 30 years participated in the study. The variables measured were height, mass, maximal oxygen consumption, muscular endurance, muscular power, muscular strength, FVC, FEV1, and reaction time. When the scores obtained after ingestion of theophylline and a placebo with a double-blind, crossover technique were compared, no significant difference was found for any of these variables. A two-way analysis of variance of FEV1 scores obtained before and after maximal exercise revealed no significant "F" ratios. This indicated that none of these trained athletes demonstrated exercise-induced asthma and that there was no difference in airway resistance after maximal exercise while they were under the influence of theophylline or placebo. We conclude that no ergogenic effects were attributable to theophylline therapy which should therefore remain an acceptable means of management of athletes with asthma participating in international sporting events.
A R Morton; C A Scott; K D Fitch
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  83     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-03-09     Completed Date:  1989-03-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  AIM; IM    
Department of Human Movement Studies, University of Western Australia, Nedlands.
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MeSH Terms
Forced Expiratory Volume
Heart Rate / drug effects
Oxygen Consumption / drug effects
Physical Endurance / drug effects*
Physical Exertion / drug effects*
Physical Fitness*
Psychomotor Performance / drug effects
Theophylline / adverse effects,  blood*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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