| The effects of temperature acclimation on monoamine metabolism. | |
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MedLine Citation:
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PMID: 909074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serotonin and dopamine content in the central nervous system of Mytilus edulis (Bivalvia) was assayed fluorometrically. Acclimating the animals for 2 to 4 days at a constant temperature higher than the environmental temperatures produced substantial increases in endogenous central nervous system serotonin and decreases in dopamine. p-Chlorophenylalanine and alpha-propyldopacetamide not only prevented this increase but reduced serotonin levels below those of unacclimated animals. Cycloheximide decreased the magnitude of the serotonin rise due to acclimation. Endogenous gill serotonin after acclimation also was higher. Gill filaments closest to the visceral ganglia were the first to increase. The study shows that hydroxylation of tryptophan is a temperature-sensitive step and axonal transport of tryptophan hydroxylase to the periphery accounts for terminal serotonin synthesis. A central pool of serotonin distinct from the peripheral pool was demonstrated. The study supports previous evidence of dopamine exerting a regulatory influence on serotonin metabolism in M. edulis. |
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Authors:
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G B Stefano; E J Catapane |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 203 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1977 Nov |
Date Detail:
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Created Date: 1977-11-30 Completed Date: 1977-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 449-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization* Animals Bivalvia / drug effects, metabolism* Central Nervous System / metabolism Dopamine / metabolism* Gills / metabolism Serotonin / metabolism* Temperature* Tryptophan Hydroxylase / metabolism |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; EC 1.14.16.4/Tryptophan Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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