| The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high-resolution manometry and videofluoroscopy. | |
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MedLine Citation:
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PMID: 16984495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Tegaserod is a partial 5-hydroxytryptamine 4 receptor agonist with prokinetic effects on the gastrointestinal tract, its effects on oesophageal function are unknown. AIM: A randomized, placebo controlled, double-blind trial assessed the effect of tegaserod on the oesophagus in healthy, asymptomatic subjects. METHOD: A 7-day course of tegaserod 6 mg b.d. vs. placebo was prescribed (n = 17/21 completed both phases of study). High-resolution manometry and pH measurements were performed before and after a test meal. Bolus transport of liquids and solids was studied by high-resolution manometry and videofluoroscopy. RESULTS: Tegaserod had no effect on lower oesophageal sphincter pressure compared with placebo, peristaltic velocity increased (P < 0.001) and distal contractile pressure decreased slightly (P < 0.05). Transient lower oesophageal sphincter relaxations and reflux were infrequent regardless of treatment. During the studies of bolus transport, high-resolution manometry revealed that tegaserod promoted mid-oesophageal contractility (P < 0.02) and shortened the 'proximal transition zone' (P < 0.05), the level where bolus escape occurred most frequently. These effects had no effect on liquid bolus transport; however a non-significant trend to improved solid bolus transport was observed (66% vs. 31%;P = 0.07). CONCLUSION: Tegaserod did not alter lower oesophageal sphincter pressure, but had significant effects on peristaltic function. High-resolution manometry promoted mid-oesophageal contractility during bolus transport. This effect was associated with a non-significant trend to improved solid bolus transit. |
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Authors:
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M Fox; D Menne; B Stutz; M Fried; W Schwizer |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 24 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-20 Completed Date: 2007-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 1017-27 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, University Hospital of Zürich, Rämistrasse, Zürich, Switzerland. markfox_2@hotmail.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Double-Blind Method Esophagus / physiology*, physiopathology Female Fluoroscopy / methods* Gastrointestinal Agents / therapeutic use* Humans Indoles / therapeutic use* Male Manometry / methods* |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 0/Indoles; 145158-71-0/tegaserod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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