Document Detail


The effects of tamsulosin and sildenafil in separate and combined regimens on detailed hemodynamics in patients with benign prostatic enlargement.
MedLine Citation:
PMID:  17085157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We measured the detailed hemodynamic effects of tamsulosin and sildenafil separately and together in patients with benign prostatic enlargement. MATERIALS AND METHODS: The supine effects of and responses to passive orthostasis (60 degrees for 8 minutes) were measured in 16 patients with benign prostatic enlargement with the finger blood pressure method and whole-body impedance cardiography. The medications, 100 mg sildenafil (single doses) and 0.4 mg tamsulosin (once daily for up to 14 days), were administered in a randomized, double-blind, crossover fashion. RESULTS: Supine systolic arterial pressure decreased with sildenafil (mean +/- SEM -11 +/- 2 mm Hg) and sildenafil plus tamsulosin (-14 +/- 2 mm Hg) more than with placebo (-2 +/- 4 mm Hg, p <0.05). In comparison to placebo sildenafil plus tamsulosin decreased the systemic vascular resistance index (328 +/- 129 vs -241 +/- 134 dyn.sec/cm.m, p = 0.01). Tamsulosin alone did not cause any significant changes in comparison to placebo. Heart rate, diastolic arterial pressure, stroke index, cardiac index and arterial pulse wave velocity were not affected to a statistically significant degree by any of the treatments compared to placebo. Upon head-up tilt the drugs caused only 1 significant change in that diastolic arterial pressure was significantly higher (-2.7 vs -8.0 mm Hg, p = 0.04) in the placebo group than in the tamsulosin plus sildenafil group. CONCLUSIONS: Tamsulosin does not disturb hemodynamics in patients with benign prostatic enlargement. Sildenafil decreases blood pressure with the patient supine but not during head-up tilt. The combination treatment also decreases the systemic vascular resistance index in the supine position.
Authors:
Tuomo Nieminen; Teuvo L J Tammela; Tiit Kööbi; Mika Kähönen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of urology     Volume:  176     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2006-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2551-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacological Sciences, Medical School, University of Tampere, Medisiinarinkatu, Tampere 33014, Finland. tuomo.nieminen@iki.fi
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MeSH Terms
Descriptor/Qualifier:
3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors*
Adrenergic alpha-Antagonists / therapeutic use*
Aged
Algorithms
Blood Pressure / drug effects
Cardiography, Impedance
Cross-Over Studies
Double-Blind Method
Drug Therapy, Combination
Heart Rate / drug effects
Humans
Male
Middle Aged
Piperazines / administration & dosage*,  therapeutic use
Prostatic Hyperplasia / drug therapy*,  physiopathology*
Purines
Sulfonamides / administration & dosage*,  therapeutic use
Sulfones
Tilt-Table Test
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Piperazines; 0/Purines; 0/Sulfonamides; 0/Sulfones; 106133-20-4/tamsulosin; 139755-83-2/sildenafil; EC 3.1.4.35/3',5'-Cyclic-GMP Phosphodiesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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