| The effects of tamsulosin and sildenafil in separate and combined regimens on detailed hemodynamics in patients with benign prostatic enlargement. | |
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MedLine Citation:
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PMID: 17085157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We measured the detailed hemodynamic effects of tamsulosin and sildenafil separately and together in patients with benign prostatic enlargement. MATERIALS AND METHODS: The supine effects of and responses to passive orthostasis (60 degrees for 8 minutes) were measured in 16 patients with benign prostatic enlargement with the finger blood pressure method and whole-body impedance cardiography. The medications, 100 mg sildenafil (single doses) and 0.4 mg tamsulosin (once daily for up to 14 days), were administered in a randomized, double-blind, crossover fashion. RESULTS: Supine systolic arterial pressure decreased with sildenafil (mean +/- SEM -11 +/- 2 mm Hg) and sildenafil plus tamsulosin (-14 +/- 2 mm Hg) more than with placebo (-2 +/- 4 mm Hg, p <0.05). In comparison to placebo sildenafil plus tamsulosin decreased the systemic vascular resistance index (328 +/- 129 vs -241 +/- 134 dyn.sec/cm.m, p = 0.01). Tamsulosin alone did not cause any significant changes in comparison to placebo. Heart rate, diastolic arterial pressure, stroke index, cardiac index and arterial pulse wave velocity were not affected to a statistically significant degree by any of the treatments compared to placebo. Upon head-up tilt the drugs caused only 1 significant change in that diastolic arterial pressure was significantly higher (-2.7 vs -8.0 mm Hg, p = 0.04) in the placebo group than in the tamsulosin plus sildenafil group. CONCLUSIONS: Tamsulosin does not disturb hemodynamics in patients with benign prostatic enlargement. Sildenafil decreases blood pressure with the patient supine but not during head-up tilt. The combination treatment also decreases the systemic vascular resistance index in the supine position. |
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Authors:
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Tuomo Nieminen; Teuvo L J Tammela; Tiit Kööbi; Mika Kähönen |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of urology Volume: 176 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-06 Completed Date: 2006-12-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 2551-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pharmacological Sciences, Medical School, University of Tampere, Medisiinarinkatu, Tampere 33014, Finland. tuomo.nieminen@iki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3',5'-Cyclic-GMP Phosphodiesterases
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antagonists & inhibitors* Adrenergic alpha-Antagonists / therapeutic use* Aged Algorithms Blood Pressure / drug effects Cardiography, Impedance Cross-Over Studies Double-Blind Method Drug Therapy, Combination Heart Rate / drug effects Humans Male Middle Aged Piperazines / administration & dosage*, therapeutic use Prostatic Hyperplasia / drug therapy*, physiopathology* Purines Sulfonamides / administration & dosage*, therapeutic use Sulfones Tilt-Table Test Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Piperazines; 0/Purines; 0/Sulfonamides; 0/Sulfones; 106133-20-4/tamsulosin; 139755-83-2/sildenafil; EC 3.1.4.35/3',5'-Cyclic-GMP Phosphodiesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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