Document Detail

The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters.
MedLine Citation:
PMID:  16481156     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to examine the effects of two different isomers of conjugated linoleic acid (CLA), c9,t11 CLA and t10,c12 CLA, compared with linoleic acid (LA) used as control, on body composition, lipoprotein profile, hepatic lipids and fecal fat content in hamsters. Animals were assigned to the three diet groups (n=15) during 28 days. The diet was composed of 2% of the experimental fat, and throughout the experimental protocol, the hamsters experienced similar food intake. No significant differences were noted in body weight gain among the three diet groups. However, the t10,c12 CLA-fed animals showed higher low-density lipoprotein cholesterol (LDL-C) concentrations (0.9+/-0.1 mmol/L) than those who ingested either LA (0.6+/-0.1 mmol/L) or c9,t11 CLA isomer (0.7+/-0.1 mmol/L), although the t10,c12 CLA consumption decreased hepatic cholesterol and triglycerides and increased fecal fat content compared with the other two groups. Under the present experimental conditions, the dietary c9,t11 CLA isomer showed no positive beneficial effect on plasma lipids. Furthermore, the t10,c12 CLA isomer induced undesirable higher LDL-C, although it reduced hepatic lipids and fat digestibility in hamsters.
Vishnee Bissonauth; Yvan Chouinard; Johanne Marin; Nadine Leblanc; Denis Richard; Hélène Jacques
Related Documents :
17495596 - The role of neutral lipases in human adipose tissue lipolysis.
19390166 - Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multipl...
2199286 - Brown adipose tissue thermogenesis: interdisciplinary studies.
11238766 - Fatty acid composition of adipose tissue and serum lipids are valid biological markers ...
434106 - Role of endothelium and hypercholesterolemia in intimal thickening and lipid accumulation.
10785986 - Issues in managing hyperlipidaemia.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-17
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  17     ISSN:  0955-2863     ISO Abbreviation:  J. Nutr. Biochem.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-18     Completed Date:  2006-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  597-603     Citation Subset:  IM    
Department of Food Science and Nutrition, Laval University, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Composition / drug effects*
Cholesterol, LDL / metabolism
Dietary Fats / pharmacology
Fats / analysis
Feces / chemistry
Linoleic Acids, Conjugated / pharmacology*
Lipid Metabolism / drug effects*
Liver / drug effects,  metabolism
Reg. No./Substance:
0/Cholesterol, LDL; 0/Dietary Fats; 0/Fats; 0/Linoleic Acids, Conjugated; 0/cis-9, trans-11-conjugated linoleic acid; 0/trans-10,cis-12-conjugated linoleic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid diso...
Next Document:  Food products and allergy development, prevention and treatment.