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The effects of systemic {alpha}1-adrenoreceptor antagonists on pupil diameter.
MedLine Citation:
PMID:  22021005     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AimTo assess differences in pupil diameter between men taking systemic α(1)-adrenoreceptor antagonists and controls.SettingUniversity of Michigan clinics, USA.MethodsMale patients over the age of 50 years were recruited from clinics over 3 months and divided into two groups: 18 study patients taking α(1)-adrenoreceptor antagonists (Flomax, Uroxatral, Cardura and Hytrin) and 31 control patients who had never been on them. Those with conditions known to affect pupil diameter were excluded. Pre-dilation pupil diameters were recorded using a pupillometer in mesopic and scotopic conditions. Right eyes were dilated with phenylephrine and tropicamide, and the left eye served as an undilated control. Following dilation, pupil diameters were measured in both lighting conditions.ResultsNo statistically significant difference was found in pupil mydriasis of patients taking α(1)-antagonists versus controls (mesopic p=0.37, scotopic p=0.67). When considering only those patients taking tamsulosin, the lack of significance remained. The duration of time on the medication did not have a statistically significant effect on pupil mydriasis. Comparison of pupil diameters of patients on tamsulosin with those on non-selective α(1)-antagonists, both before and after dilation, showed no significant difference in pupil mydriasis (mesopic p=0.77, scotopic p=1.00).ConclusionsThe outcomes of this study present an interesting contrast to current literature. Previously, it had been hypothesised that a majority of patients taking α(1)-antagonists would experience preoperative impairment of pupil dilation. The authors found no significant decrease in pupil diameters of patients on α(1)-adrenoreceptor antagonists compared with controls, and no indication that duration or medication subtype had an effect.
Authors:
Theresa M Cooney; Albert Wu; Geoffrey Wilkes; Jerome I Finkelstein; David C Musch
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-22
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  -     ISSN:  1468-2079     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Michigan, Ann Arbor, Michigan, USA.
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