Document Detail

The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.
MedLine Citation:
PMID:  8637535     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Athletes often take androgenic steroids in an attempt to increase their strength. The efficacy of these substances for this purpose is unsubstantiated, however. METHODS: We randomly assigned 43 normal men to one of four groups: placebo with no exercise; testosterone with no exercise; placebo plus exercise; and testosterone plus exercise. The men received injections of 600 mg of testosterone enanthate or placebo weekly for 10 weeks. The men in the exercise groups performed standardized weight-lifting exercises three times weekly. Before and after the treatment period, fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging, and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively. RESULTS: Among the men in the no-exercise groups, those given testosterone had greater increases than those given placebo in muscle size in their arms (mean [+/-SE] change in triceps area, 424 +/- 104 vs. -81 +/- 109 square millimeters; P < 0.05) and legs (change in quadriceps area, 607 +/- 123 vs. -131 +/- 111 square millimeters; P < 0.05) and greater increases in strength in the bench-press (9 +/- 4 vs. -1 +/- 1 kg, P < 0.05) and squatting exercises (16 +/- 4 vs. 3 +/- 1 kg, P < 0.05). The men assigned to testosterone and exercise had greater increases in fat-free mass (6.1 +/- 0.6 kg) and muscle size (triceps area, 501 +/- 104 square millimeters; quadriceps area, 1174 +/- 91 square millimeters) than those assigned to either no-exercise group, and greater increases in muscle strength (bench-press strength, 22 +/- 2 kg; squatting-exercise capacity, 38 +/- 4 kg) than either no-exercise group. Neither mood nor behavior was altered in any group. CONCLUSIONS: Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men.
S Bhasin; T W Storer; N Berman; C Callegari; B Clevenger; J Phillips; T J Bunnell; R Tricker; A Shirazi; R Casaburi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  335     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-07-11     Completed Date:  1996-07-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  AIM; IM    
Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
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MeSH Terms
Affect / drug effects
Anger / drug effects
Behavior / drug effects
Body Weight / drug effects
Double-Blind Method
Gonadotropins, Pituitary / blood
Injections, Intramuscular
Lipids / blood
Muscle, Skeletal / drug effects*,  physiology
Sex Hormone-Binding Globulin / analysis
Testosterone / administration & dosage*,  blood
Weight Lifting / physiology*
Grant Support
1 RO1 DK 45211/DK/NIDDK NIH HHS; MO-00543//PHS HHS; P20RR11145-01/RR/NCRR NIH HHS
Reg. No./Substance:
0/Gonadotropins, Pituitary; 0/Lipids; 0/Sex Hormone-Binding Globulin; 58-22-0/Testosterone
Comment In:
N Engl J Med. 1996 Jul 4;335(1):52-3   [PMID:  8637543 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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