| The effects of subconjunctival verapamil on filtering blebs in rabbits. | |
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MedLine Citation:
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PMID: 8860605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Verapamil is a calcium antagonist that has been shown to modulate wound healing through multiple mechanisms. The wound modulating effects of verapamil were studied in a rabbit model of filtering surgery. MATERIALS AND METHODS: Twenty New Zealand albino rabbits underwent a fistulizing procedure, with either verapamil or saline injected subconjunctivally daily for 6 days following surgery. The animals were sacrificed at 20 days after the fistulizing procedure. The effectiveness of verapamil in modulating wound healing was evaluated by bleb patency testing, histology, measurement of scar thickness, and counts of bromodeoxyuridine (BrdU)-labeled cells at the sclerostomy site. RESULTS: The group treated with verapamil had a 44 percent patency rate compared with 10 percent in the control group (P < .05), a mean scar thickness of 195.96 +/- 68 mu m compared with 313.55 +/- 110.4 mu m in the control group (P < .02), and a mean BrdU-labeled cell count of 15.5 +/- 14.7 compared with 26.3 +/- 17.0 in the control group (P < .002). CONCLUSION: Verapamil was effective in reducing scar formation at the sclerostomy site. At the doses administered, verapamil appeared to modulate wound healing in filtering blebs in the rabbit model. Further studies are needed to determine the dose-response and the efficacy of the drug in nonhuman primates. |
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Authors:
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B Gupta; A Agarwala; J J Moy; D P Edward |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Ophthalmic surgery and lasers Volume: 27 ISSN: 1082-3069 ISO Abbreviation: Ophthalmic Surg Lasers Publication Date: 1996 May |
Date Detail:
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Created Date: 1997-05-19 Completed Date: 1997-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9517132 Medline TA: Ophthalmic Surg Lasers Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 378-83 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Eye and Ear Infirmary, University of Illinois at Chicago, Ill, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channel Blockers / administration & dosage, pharmacology* Cell Division Conjunctiva DNA Replication / drug effects Disease Models, Animal Dose-Response Relationship, Drug Follow-Up Studies Injections Rabbits Sclera / drug effects*, pathology Sclerostomy* Treatment Outcome Verapamil / administration & dosage, pharmacology* Wound Healing / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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