Document Detail

The effects of subclinical fasciolosis on hepatic secretory function in sheep.
MedLine Citation:
PMID:  7731919     Owner:  NLM     Status:  MEDLINE    
The effects of subclinical fasciolosis at various stages of its development on bile flow and bile acid secretion and on the hepatobiliary transport of bilirubin were investigated in experimentally infected sheep. Bile flow was significantly reduced by weeks 6-14 postinfection. This was accompanied by a decrease in bile acid secretion by weeks 6-8. Serum AST and GLDH activities and serum bile acid concentration were significantly elevated from weeks 6 to 14. Total serum bilirubin was maximally increased at 6 weeks postinfection and remained elevated at weeks 8 and 14. Increases corresponded to both unconjugated and conjugated fractions, although the conjugated/total bilirubin ratio was enhanced in all infected animals. Biliary bilirubin secretion declined from weeks 6 to 14. No alteration was detected in either uridine diphosphate (UDP)-glucuronosyltransferase activity, cytochrome P-450 concentration, or hematological markers of hemolysis. This study shows that the migration of immature flukes in the course of ovine fasciolosis causes a cholestatic phenomenon responsible for changes in serum and biliary bilirubin levels.
I Ferre; P López; M Gonzalo-Orden; M D Julian; F A Rojo-Vázquez; J González-Gallego
Related Documents :
17876519 - Bile acids and their signaling pathways: eclectic regulators of diverse cellular functi...
9461519 - Regulation of expression of human intestinal bile acid-binding protein in caco-2 cells.
7851209 - Toxic effects of cholelitholytic solvents on gallbladder and liver. a piglet model study.
7134829 - Postprandial serum bile acids in resected and non-resected patients with crohn's disease.
236159 - The metabolism and disposition of aniline in the isolated blood-perfused liver of the rat.
7155919 - Fecal steroids and urinary volatile phenols in four scandinavian populations.
8951169 - Amino acid sequences and ribosome-inactivating activities of karasurin-b and karasurin-c.
18378229 - Comparative efficacy of topical antihistamines in an animal model of early phase allerg...
18657419 - Effects of the maturity of wood waste compost on the structural features of humic acids.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasitology research     Volume:  81     ISSN:  0932-0113     ISO Abbreviation:  Parasitol. Res.     Publication Date:  1995  
Date Detail:
Created Date:  1995-06-01     Completed Date:  1995-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  127-31     Citation Subset:  IM    
Department of Physiology, Pharmacology and Toxicology, University of León, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bile / secretion*
Bilirubin / blood
Cytochrome P-450 Enzyme System / metabolism
Fascioliasis / pathology,  physiopathology,  veterinary*
Glucuronosyltransferase / metabolism
Liver / pathology,  physiopathology*
Reference Values
Sheep Diseases*
Time Factors
Reg. No./Substance:
635-65-4/Bilirubin; 9035-51-2/Cytochrome P-450 Enzyme System; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The involvement of terminal carbohydrates of the mammalian cell surface in the cytoadhesion of trich...
Next Document:  Use of enzyme-linked immunosorbent assay and enzyme-linked immunoelectrotransfer blot for the diagno...