| The effects of streptozocin-induced diabetes on renal plasma flow. | |
| | |
MedLine Citation:
|
PMID: 8788309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To evaluate the significance of collagen levels, nonenzymatic glycation, and effective renal plasma flow in diabetes, we studied 52 Streptozocin induced-diabetic rats. After 10 weeks of diabetes, rats were injected i.v. 0.5 microCi/g 99mTechnetium Mercaptoacetyl triglycine and effective renal plasma flow was calculated from the renograms obtained. The collagen content and hydroxymethyl furfural levels of kidney and tail tissue as well as renal plasma flow increased significantly in diabetic rats (p < 0.05). The increase in renal plasma flow indicates that hyperperfusion may play a role in diabetic nephropathy mechanism. The correlation between renal plasma flow and glycation was not as high as the correlations between blood glucose concentrations and hydroxymethyl furfural and collagen levels, suggesting that factors other than glycation are important in increasing the renal plasma flow. |
| | |
Authors:
|
A Baykal-Erkiliç; M Erkiliç; T Ozben |
Related Documents
:
|
8573729 - Prediabetic blood pressure and familial predisposition to renal disease in pima indians... 16400229 - Membranoproliferative glomerulonephritis complicating diabetic nephropathy. 1838069 - Basal and stimulated plasma atrial natriuretic factor in patients with type 1 diabetes ... 16936219 - A disease haplotype for advanced nephropathy in type 2 diabetes at the ace locus. 1944729 - Homozygous c3 deficiency associated with iga nephropathy. 1547969 - Lens fluorescence in relation to nephropathy in insulin-dependent diabetes mellitus. 10814839 - Down-regulation of orexin gene expression by severe obesity in the rats: studies in zuc... 3544179 - Clinical effects of glazing denture acrylic resin bases using an ultraviolet curing met... 12822859 - Impaired gastric emptying and altered intragastric meal distribution in diabetes mellit... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 103 ISSN: 0947-7349 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 1995 |
Date Detail:
|
Created Date: 1996-10-21 Completed Date: 1996-10-21 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 367-72 Citation Subset: IM |
Affiliation:
|
Biochemistry Department, Medical Faculty of Akdeniz University, Antalya, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Glucose / metabolism Collagen / metabolism Diabetes Mellitus, Experimental / physiopathology* Diabetic Nephropathies / physiopathology Furaldehyde / analogs & derivatives, metabolism Glycosylation Kidney / metabolism Male Rats Rats, Sprague-Dawley Renal Plasma Flow, Effective* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 67-47-0/5-hydroxymethylfurfural; 9007-34-5/Collagen; 98-01-1/Furaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The release of insulin-like growth factor-I by luteinized human granulosa cells in vitro: regulation...
Next Document: Effect of interleukin-1a, IL-1b and IL-1 receptor antibody on the proliferation and steroidogenesis ...