Document Detail


The effects of streptozocin-induced diabetes on renal plasma flow.
MedLine Citation:
PMID:  8788309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the significance of collagen levels, nonenzymatic glycation, and effective renal plasma flow in diabetes, we studied 52 Streptozocin induced-diabetic rats. After 10 weeks of diabetes, rats were injected i.v. 0.5 microCi/g 99mTechnetium Mercaptoacetyl triglycine and effective renal plasma flow was calculated from the renograms obtained. The collagen content and hydroxymethyl furfural levels of kidney and tail tissue as well as renal plasma flow increased significantly in diabetic rats (p < 0.05). The increase in renal plasma flow indicates that hyperperfusion may play a role in diabetic nephropathy mechanism. The correlation between renal plasma flow and glycation was not as high as the correlations between blood glucose concentrations and hydroxymethyl furfural and collagen levels, suggesting that factors other than glycation are important in increasing the renal plasma flow.
Authors:
A Baykal-Erkiliç; M Erkiliç; T Ozben
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  103     ISSN:  0947-7349     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  1995  
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  IM    
Affiliation:
Biochemistry Department, Medical Faculty of Akdeniz University, Antalya, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Collagen / metabolism
Diabetes Mellitus, Experimental / physiopathology*
Diabetic Nephropathies / physiopathology
Furaldehyde / analogs & derivatives,  metabolism
Glycosylation
Kidney / metabolism
Male
Rats
Rats, Sprague-Dawley
Renal Plasma Flow, Effective*
Chemical
Reg. No./Substance:
0/Blood Glucose; 67-47-0/5-hydroxymethylfurfural; 9007-34-5/Collagen; 98-01-1/Furaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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