Document Detail

The effects of statins on the progression of atherosclerotic renovascular disease.
MedLine Citation:
PMID:  17713349     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The aim was to examine the influence of statin therapy on the natural history of atherosclerotic renal artery stenosis (RAS). METHODS: Our hospital atherosclerotic renovascular disease (ARVD) database was analysed for patients who underwent repeat renal angiography during clinical follow-up. Patients with >or=1 RAS lesion and >or=4 months between baseline and repeat renal angiography were analysed. 79 patients were included. Baseline renal arterial anatomy was classified as normal, <or=50% RAS, >50% RAS or renal artery occlusion. RESULTS: Mean follow-up time between angiograms was 27.8 +/- 22.3 (4.0-101.9) months. Progression of RAS occurred in 28 (23%) vessels, regression in 14 (12%) and no significant change in 79 (65%). Multivariate regression analysis showed that baseline proteinuria >0.6 g/day increased the risk of progressive disease (relative risk, RR, 3.8; 95% confidence interval, CI, 1.2-12.1), treatment with statin reduced the risk of progression (RR 0.28; 95% CI 0.10-0.77). 14 renal arteries from 12 patients showed RAS regression with a greater proportion on statin [statin treatment 10 (83%) versus no statin treatment 2 (17%), p = 0.001]. Change in estimated glomerular filtration rate (eGFR) per year was not different between statin- and no-statin-treated groups. CONCLUSIONS: Progression or development of RAS was significantly less likely to occur with statin therapy. Delta eGFR did not correlate with progression of RAS, reflecting the importance of intrarenal injury in the aetiology of renal dysfunction. Our results suggest statin therapy can alter the natural history of ARVD.
Ching M Cheung; Amit Patel; Nilam Shaheen; Sharon Cain; Helen Eddington; Janet Hegarty; Rachel J Middleton; Alistair Cowie; Hari Mamtora; Philip A Kalra
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-08-21
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  107     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c35-42     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Department of Renal Medicine, Hope Hospital, Salford, UK.
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MeSH Terms
Atherosclerosis / diagnosis*,  drug therapy*,  etiology,  pathology
Disease Progression
Follow-Up Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Kidney Diseases / diagnosis*,  drug therapy*,  etiology,  pathology
Middle Aged
Retrospective Studies
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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