Document Detail


The effects of spinal anesthesia on QT interval in preeclamptic patients.
MedLine Citation:
PMID:  17056963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we measured the effects of spinal anesthesia on the corrected QT (QTc) interval in women with severe preeclampsia. Twenty-five preeclamptic (preeclamptic group) and 25 healthy pregnant women with normal arterial blood pressure and QTc interval (control group) were enrolled in this prospective, case-controlled study. Arterial blood pressure, heart rate, and QTc interval values were obtained before (baseline value) and at 5, 10, 20, 30, 60, and 120 min after initiation of spinal anesthesia. Total ephedrine dose, time elapsed until sensory block, and Apgar scores were recorded. Prior to spinal anesthesia, QTc interval values were significantly higher in the preeclamptic group (452 +/- 17.5 ms) when compared with that in controls (376 +/- 21.4 ms). Although the QTc interval shortened during spinal anesthesia when compared with baseline value in the preeclamptic group (P < 0.05), it showed no significant change in the control group. In conclusion, the QTc interval may be prolonged in severe preeclamptic patients who have hypertension and hypocalcemia. Spinal anesthesia for cesarean delivery may normalize that prolonged QTc interval due to sympathetic blockade.
Authors:
Selda Sen; Galip Ozmert; Hakan Turan; Eray Caliskan; Alper Onbasili; Duran Kaya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  103     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2006-11-14     Revised Date:  2007-08-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1250-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesiology, Adnan Menderes University, Aydin, Turkey. drseldasen@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, Spinal / adverse effects,  methods*
Case-Control Studies
Electrocardiography / methods
Female
Humans
Long QT Syndrome / drug therapy*,  physiopathology
Pre-Eclampsia / drug therapy*,  physiopathology
Pregnancy
Prospective Studies
Comments/Corrections
Comment In:
Anesth Analg. 2007 Aug;105(2):535; author reply 536   [PMID:  17646522 ]
Anesth Analg. 2007 Aug;105(2):535-6; author reply 536   [PMID:  17646521 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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