Document Detail


The effects of sotalol on ventricular repolarization during exercise.
MedLine Citation:
PMID:  15754421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Although after pacing animal and human studies have demonstrated a rate-dependent effect of sotalol on ventricular repolarization, there is little information on the effects of sotalol on ventricular repolarization during exercise. This study attempted to show the effects of sotalol on ventricular repolarization during physiological exercise.
METHODS: Thirty-one healthy volunteers (18 males, 13 females) were enrolled in the study. Each performed a maximal treadmill exercise test according to the Bruce protocol after random treatment with sotalol, propranolol and placebo.
RESULTS: Sotalol significantly prolonged QTc (corrected QT) and JTc (corrected JT) intervals at rest compared with propranolol (QTc 324.86 ms vs 305.21 ms, P<0.001; JTc 245.04 ms vs 224.17 ms, P<0.001) and placebo (QTc 324.86 ms vs 314.06 ms, P<0.01; JTc 245.04 ms vs. 232.69 ms, P<0.001). The JTc percent reduction increased progressively with each stage of exercise and correlated positively with exercise heart rate (r=0.148, P<0.01). The JTc percent reduction correlation with exercise heart rate did not exist with either propranolol or placebo.
CONCLUSIONS: These results imply that with sotalol ventricular repolarization is progressively shortened after exercise. Thus the specific class III antiarrhythmic activity of sotalol, present as delay of ventricular repolarization, may be attenuated during exercise. Such findings may imply the need to consider other antiarrythmic therapy during periods of stress-induced tachycardia.
Authors:
Jian Li; Jian-an Wang
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  6     ISSN:  1673-1581     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-07-22     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
Affiliation:
Cardiology Department of Pu Nan Hospital, Pudong New District, Shanghai 200125, China. lj.zj @126.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise / physiology*
Exercise Test
Female
Heart / drug effects*,  physiopathology*
Heart Rate / drug effects,  physiology
Humans
Male
Sotalol / pharmacology*
Chemical
Reg. No./Substance:
3930-20-9/Sotalol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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