Document Detail


The effects of some sweetening agents and osmotic pressure on the intestinal absorption of sulfafurazole in the rat.
MedLine Citation:
PMID:  41064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of some sugars and osmotic pressure have been examined on the absorption of sulfafurazole in the rat. Statistically significant correlations were found among the hypertonic solutions between the reciprocal of osmotic pressure and AUC0--infinity or Cmax. In addition, negative correlation existed between plasma concentrations at 15 min and osmotic pressure. No significant correlations were noted among the hypotonic solutions. More attention should be paid to the osmotic pressure of formulations. The osmotic pressure of hypertonic solutions, especially, might affect absorption of drug from its dosage form.
Authors:
M Marvola; A Reinikainen; M L Heliövaara; A Huikari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  31     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-01-24     Completed Date:  1980-01-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  615-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Half-Life
Intestinal Absorption* / drug effects
Kinetics
Osmotic Pressure*
Rats
Sulfisoxazole / blood,  metabolism*
Sweetening Agents / pharmacology*
Time Factors
Viscosity
Chemical
Reg. No./Substance:
0/Sweetening Agents; 127-69-5/Sulfisoxazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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