Document Detail

The effects of sodium ampicillin, sodium cefazolin, and sodium cefoxitin on blood pressures and heart rates in healthy, anesthetized dogs.
MedLine Citation:
PMID:  10730619     Owner:  NLM     Status:  MEDLINE    
This study determined the effects of intravenous ampicillin, cefazolin, and cefoxitin on blood pressures and heart rates in healthy, anesthetized dogs. Forty dogs were each randomly assigned to a control, ampicillin, cefazolin, or cefoxitin group. Antibiotics or saline was delivered by intravenous bolus prior to surgical stimulation. Heart rate; systolic, mean, and diastolic arterial pressures; oxygen saturation; end-tidal halothane; and end-tidal carbon dioxide (CO2) were recorded before and every minute for 10 minutes after the test drug was administered. No significant differences were recorded between the antibiotic and control groups. The prophylactic use of these antibiotics should be considered safe in healthy, anesthetized dogs.
M R Morgan; J S Gaynor; E Monnet
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  36     ISSN:  0587-2871     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-04-17     Completed Date:  2000-04-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Department of Clinical Sciences, Veterinary Teaching Hospital, Colorado State University, Fort Collins 80523-1620, USA.
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MeSH Terms
Ampicillin / pharmacology*
Anesthesia / veterinary
Anti-Bacterial Agents / pharmacology*
Blood Pressure / drug effects
Cefazolin / pharmacology*
Cefoxitin / pharmacology*
Dogs / physiology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Injections, Intravenous / veterinary
Reg. No./Substance:
0/Anti-Bacterial Agents; 25953-19-9/Cefazolin; 35607-66-0/Cefoxitin; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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