Document Detail


The effects of single-dose atenolol, labetalol, and propranolol on cardiac and vascular function.
MedLine Citation:
PMID:  3742933     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacodynamic effects of single oral doses of atenolol (100 mg), labetalol (300 mg), and propranolol (80 mg) were compared with those of placebo in a randomized, double-blind, Latin square design in 12 patients with hypertension. Atenolol and propranolol both significantly reduced cardiac output (-0.55 vs. -0.31 L/min) and heart rate (-8.0 vs. -6.6 bpm), whereas labetalol had no effect on either parameter (-0.08 L/min; + 1.0 bpm). Labetalol significantly reduced vascular resistance (-339 dynes X cm/sec5), but atenolol and propranolol did not (147 vs. 62 dynes X cm/sec5). Only labetalol significantly reduced the systolic (-15.3 mm Hg), diastolic (-11.5 mm Hg), and mean blood pressures (-12.8 mm Hg). Atenolol significantly reduced only diastolic blood pressure (-5.20 mm Hg), whereas propranolol failed to lower these parameters significantly. These data indicate that the hemodynamic profile of labetalol differs from that of selective and nonselective beta-blockers. Labetalol lowered blood pressure primarily by reducing vascular resistance, whereas reductions in heart rate and cardiac output were the predominant effects of atenolol and propranolol.
Authors:
J L Holtzman; D Finley; B Johnson; D A Berry; M A Sirgo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  40     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-23     Completed Date:  1986-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-73     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Atenolol / blood,  therapeutic use*
Cardiac Output / drug effects
Cardiovascular System / drug effects*
Heart Rate / drug effects
Humans
Hypertension / drug therapy
Labetalol / blood,  therapeutic use*
Male
Middle Aged
Propranolol / blood,  therapeutic use*
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
29122-68-7/Atenolol; 36894-69-6/Labetalol; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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