Document Detail

The effects of single L-amino acid substitutions on the lethal potencies of the microcystins.
MedLine Citation:
PMID:  2506678     Owner:  NLM     Status:  MEDLINE    
Microcystin-LR and -LA are more toxic than microcystin-LY and -RR in adult mice. They induce different degrees of thrombocytopenia and leukopenia, and the lethalities of their binary and ternary mixtures are addictive. Postnatal mice are resistant to doses of microcystin-LR that are lethal to adults but they are susceptible to higher doses. Substitution of a single L-amino acid for another in a microcystin markedly affects the dosimetric potency, but not the pathophysiology of its toxicity.
R D Stoner; W H Adams; D N Slatkin; H W Siegelman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  27     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-20     Completed Date:  1989-10-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  825-8     Citation Subset:  IM    
Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973.
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MeSH Terms
Amino Acids
Animals, Newborn / physiology
Bacterial Toxins*
Cyanobacteria / analysis*
Injections, Intraperitoneal
Lethal Dose 50
Marine Toxins / analysis,  toxicity*
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Bacterial Toxins; 0/Marine Toxins; 0/Microcystins; 0/cyanobacterial toxin

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