Document Detail


The effects of simultaneous atropine and labetalol administration on cardiovascular parameters during anticholinesterase poisoning in anaesthetized cat.
MedLine Citation:
PMID:  3608237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of atropine administration during anticholinesterase poisoning on heart rate, blood pressure and electrocardiographic changes (ECG) were studied in the cat. Administration of atropine intravenously during anticholinesterase poisoning caused a significant increase in heart rate and blood pressure; ECG changes were also seen. The simultaneous intravenous administration of atropine and labetalol during anticholinesterase poisoning abolished the increase in blood pressure and heart rate; ECG readings remained normal. It is suggested that labetalol may be a useful adjuvant in the treatment of anticholinesterase poisoning especially in patients with compromised heart function.
Authors:
Z Merican; Z Mahmud; P Morat; S Z Idid; K Bi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  14     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / antagonists & inhibitors*,  therapeutic use
Cats
Cholinesterase Inhibitors / poisoning*
Drug Therapy, Combination
Female
Hemodynamics / drug effects*
Labetalol / therapeutic use*
Male
Neostigmine / poisoning
Chemical
Reg. No./Substance:
0/Cholinesterase Inhibitors; 36894-69-6/Labetalol; 51-55-8/Atropine; 59-99-4/Neostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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