Document Detail

The effects of simultaneous atropine and labetalol administration on cardiovascular parameters during anticholinesterase poisoning in anaesthetized cat.
MedLine Citation:
PMID:  3608237     Owner:  NLM     Status:  MEDLINE    
The effects of atropine administration during anticholinesterase poisoning on heart rate, blood pressure and electrocardiographic changes (ECG) were studied in the cat. Administration of atropine intravenously during anticholinesterase poisoning caused a significant increase in heart rate and blood pressure; ECG changes were also seen. The simultaneous intravenous administration of atropine and labetalol during anticholinesterase poisoning abolished the increase in blood pressure and heart rate; ECG readings remained normal. It is suggested that labetalol may be a useful adjuvant in the treatment of anticholinesterase poisoning especially in patients with compromised heart function.
Z Merican; Z Mahmud; P Morat; S Z Idid; K Bi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  14     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
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MeSH Terms
Atropine / antagonists & inhibitors*,  therapeutic use
Cholinesterase Inhibitors / poisoning*
Drug Therapy, Combination
Hemodynamics / drug effects*
Labetalol / therapeutic use*
Neostigmine / poisoning
Reg. No./Substance:
0/Cholinesterase Inhibitors; 36894-69-6/Labetalol; 51-55-8/Atropine; 59-99-4/Neostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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