Document Detail

The effects of sex-steroids on the synthesis of uterine non-histone proteins.
MedLine Citation:
PMID:  832765     Owner:  NLM     Status:  MEDLINE    
Newly synthesized non-histone proteins (NHP) labelled with [35S] methionine were isolated from uterine epithelium and stroma after different hormone treatments and examined by isoelectric focusing in polyacrylamide gels. Progesterone increased the proportion of basic NHP in the epithelium. This effect was detectable within 4 h and was maintained unchanged after oestrogen stimulation, which increased the synthesis of all classes of NHP. The proportion of basic NHP was higher in the untreated stroma than in the epithelium. Progesterone pretreatment did not increase the proportion of basic NHP in the stroma but prevented the increase in the more acidic NHP which followed treatment with oestrogen alone. The tendency to synthesize a higher proportion of basic NHP did not in any way correlate with the tissue's proliferative status.
J W Pollard; L Martin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  6     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-03-21     Completed Date:  1977-03-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  223-9     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / drug effects,  metabolism
Chromosomal Proteins, Non-Histone / biosynthesis*
Estradiol / pharmacology*
Progesterone / pharmacology*
Uterus / drug effects,  metabolism*
Reg. No./Substance:
0/Chromosomal Proteins, Non-Histone; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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